Post Doctoral Research Associate
University of Cambridge
Tennis Court Road
Cambridge
CB2 1QP
Research Interests
My current work involves deciphering signaling pathways with-in the host cells that are hijacked by Gram negative bacteria such as Salmonella, EPEC, and Shigella etc. to facilitate their own invasion and survival in host cells. To cause disease these pathogens must establish intracellular infections, which they achieve by delivering virulence proteins into target host-epithelial cells. These virulence proteins or “effectors” act in cohort by hijacking master regulators of Ras family small GTPases (e.g. Rho, Arf and Rab GTPases). By manipulating Rho and Arf GTPases that control the host cell’s actin cytoskeleton, these pathogens are able to remodel the host cell surface plasma membrane and trigger their own uptake into the cells.
Collaborators
Key Publications
Salmonella and Host interplay
1. Peter J Hume, Vikash Singh, Anthony Davidson, V Koronakis. Frontiers in Cellular and Infection Microbiology;Jul, 2017.
2.
Actin Dynamics: Role of GTPases
1. Arf GTPase interplay with Rho GTPases in regulation of the actin cytoskeleton. V Singh, AC Davidson, P Hume, D Humphreys and V Koronakis. Small GTPases; May, 2017.
Organic Chemistry Application
1. Utilizing a series of fac- Re(CO) 3 core based quinonoid containing complexes for photophysical and cell imaging studies. Deepak Gupta, Vikash Singh, Stephan Hohloch, Malaichamy Sathiyendiran, Karsten Tedin, Biprajit Sarkar. Polyhedyron ;Jul 2015.
Educational/ teaching tips
Scientific Writing: Strategies and Tools for Students and Advisors. Vikash Singh and Philipp Mayer. Biochemistry and Molecular Biology Education; Sept, 2014