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Dr. Vikash Singh

Dr. Vikash Singh

Post Doctoral Research Associate

Department of Pathology
University of Cambridge
Tennis Court Road
Cambridge
CB2 1QP

Research Interests

My current work involves deciphering signaling pathways with-in the host cells that are hijacked by Gram negative bacteria such as Salmonella, EPEC, and Shigella etc. to facilitate their own invasion and survival in host cells. To cause disease these pathogens must establish intracellular infections, which they achieve by delivering virulence proteins into target host-epithelial cells. These virulence proteins or “effectors” act in cohort by hijacking master regulators of Ras family small GTPases (e.g. Rho, Arf and Rab GTPases). By manipulating Rho and Arf GTPases that control the host cell’s actin cytoskeleton, these pathogens are able to remodel the host cell surface plasma membrane and trigger their own uptake into the cells.

Key Publications

Salmonella and Host interplay

1. Swiss Army Pathogen: The Salmonella Entry Toolkit    Peter J Hume, Vikash Singh, Anthony Davidson, V Koronakis. Frontiers in Cellular and Infection Microbiology;Jul, 2017.

2. MYO6 is targeted by Salmonella virulence effectors to trigger PI3-Kinase signalling and pathogen invasion into host cells. A B. E. Brooks, Daniel Humphreys, Vikash Singh, A C. Davidson, S D.Arden, Folma Buss, Vassilis Koronakis. PNAS; Feb 2017

3. Salmonella co-opts host cell chaperone-mediated autophagy for intracellular growth. Vikash Singh, Johannes Finke-Isami, Amanda C. Hopper-Chidlaw, Peter Schwerk, A. Thompson, Karsten Tedin. JBC;Dec, 2016

4. The Salmonella Typhimurium effector protein SopE transiently localizes to the early SCV and contributes to intracellular replication. Pascale Vonaesch, Steven Cardini, Vikash Singh, Manja Barthel, W.D Hardt. Cellular Microbiology;Jul, 2014

5.  Salmonella Serovars and Their Host Specificity. Vikash Singh. Journal of Veterinary Biology;Dec, 2013.

1. Inhibition of WAVE Regulatory Complex Activation by a Bacterial Virulence Effector Counteracts Pathogen Phagocytosis.  Daniel Humphreys, Vikash Singh, Vassilis Koronakis. Cell Reports;Oct, 2016.

Actin Dynamics: Role of GTPases

1. Arf GTPase interplay with Rho GTPases in regulation of the actin cytoskeleton. V Singh, AC Davidson, P Hume, D Humphreys and V Koronakis. Small GTPases; May, 2017.

Organic Chemistry Application

1. Utilizing a series of fac- Re(CO) 3 core based quinonoid containing complexes for photophysical and cell imaging studies. Deepak Gupta, Vikash Singh, Stephan Hohloch, Malaichamy Sathiyendiran, Karsten Tedin, Biprajit Sarkar. Polyhedyron ;Jul 2015.

Educational/ teaching tips

Scientific Writing: Strategies and Tools for Students and Advisors. Vikash Singh and Philipp Mayer. Biochemistry and Molecular Biology Education; Sept, 2014