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Fully-funded PhD studentships

Department of Pathology fully-funded PhD studentships January 2019 entry

A PhD studentship is available to work in Professor G L Smith’s laboratory to investigate the mechanism by which vaccinia virus exploits microtubules to transport new virions to the cell periphery. The position is available from January 2019 or as soon thereafter as the suitable candidate can start. 

Applicants should have a 1st or upper second class degree in biological or medical sciences and preferably some experience of working in a research environment. Additionally, the Department requires that by the time of interview all potential students must have fulfilled the Language Requirements for admission.

Funding will cover the student’s stipend at the current Research Council rate and University Fees. The studentships will be funded for three years in the first instance subject to eligibility*, with the possibility of additional funding in the fourth year depending on circumstances.

*The studentships are available to students who qualify for Home/EU fees

Applications from ineligible candidates will not be considered.

Fixed-term: The funds for this post are available for 3 years in the first instance. 

General queries regarding these positions should be directed to graduate.studies@path.cam.ac.uk or 01223 333940.

Closing date for applications: December 21st 2018. All applications should be made online via the University’s Applicant Portal.

Project details 

Vaccinia virus is the live vaccine that was used to eradicate smallpox. After smallpox eradication, VACV has been exploited to build vaccines against other diseases and continues to be studied to better understand virus interactions with the host cell and the immune system. This project will study how vaccinia virus exploits the kinesin-1 motor to transport newly synthesised virus particles on microtubules to the cell periphery. Specifically, the project with study the functions of the virus proteins A36, F12 and E2 in this process and the cellular proteins to which they bind, such as kinesin light chains 1 and 2. 

References 

Doceul, V., Hollinshead, M., van der Linden, L. & Smith, G.L. (2010). Repulsion of superinfecting virions: a mechanism for rapid virus spread. Science, 327, 873-7. 

Carpentier, D.C.J., Gao, W.N.D., Ewles, H., Morgan, G.W. & Smith, G.L. (2015). Vaccinia virus protein complex F12/E2 interacts with kinesin light chain isoform 2 to engage the kinesin-1 motor complex. PLoS Pathogens. 11, e1004723. 

Gao, W.N.D., Carpentier, D.C.J., Ewles, H.A., Lee, S.-A. & Smith, G.L. (2017). Vaccinia virus proteins A36 and F12/E2 show strong preferences for different kinesin light chain isoforms. Traffic 18, 505-18. 

Carpentier, D.C.J., Van Loggerenberg, A., Dieckmann, N.M.G. & Smith, G.L. (2017). Vaccinia virus egress mediated by protein A36 is reliant on the F12 protein. J. Gen. Virol. 98, 1500-14.

 

Department of Pathology fully-funded PhD studentships October 2019 entry

 

The Department of Pathology has an excellent reputation in pure biological and biomedical research and is offering fully funded* studentships from October 2019 to work with one of the Research Group Leaders in this large and vibrant Department. 

All applications should be made online via the University’s Applicant Portal. In the Studentship section of your application please enter the projects that you are applying for in order of preference. You are allowed to select up to 3. An application is only complete when all supporting documents, including the 2 academic references, are submitted. It is the applicants responsibility to ensure their referees submit their references before the closing date.

The list of available projects is shown below. Applicants can select up to a maximum of three supervisors/projects, although this is not a requirement. Applicants should hold or be about to achieve a First or Upper-Second (2.i) class degree in a relevant subject. Additionally, the Department requires that by the time of interview all potential students must have fulfilled the Language Requirements for admission.

 Deadline for applications: 3rd January 2019

Supervisors and Projects available for October 2019 are:

Dr Isaia Barbieri: Understanding the role of the Guanosine Trimethylase TGS1 in Acute myeloid leukaemia (ib318@cam.ac.uk)

Dr Betty Chung: Early PI3-mediated translation response during intracellular bacterial and viral infection (bcy23@cam.ac.uk)

Dr Paolo D’Avino: Characterization of the roles of PP1 phosphatases in cytokinesis (ppd21@cam.ac.uk) 

Prof Ming Du: Characterization of clonal evolution of T-cell lymphoma (mqd20@cam.ac.uk) 

Dr James Edgar: Tetherin exosomes (je333@cam.ac.uk) 

Prof Ian Goodfellow: Characterisation of the mechanism of norovirus VPg-dependent RNA synthesis. (ig299@cam.ac.uk)

Dr Nerea Irigoyen: Understanding Zika virus pathogenesis in human neurons (ni236@cam.ac.uk) 

Dr Catherine Merrick: How do malaria parasites sense and respond to DNA damage?  (cjm48@cam.ac.uk) 

Funding* will cover the student’s stipend at the current Research Council rate and University Fees. The studentships will be funded for three years in the first instance subject to eligibility**, with the possibility of additional funding in the fourth year depending on circumstances.

**The studentships are available to students who qualify for Home/EU fees

Applications from ineligible candidates will not be considered.

Fixed-term: The funds for this post are available for 3 years in the first instance. 

General queries regarding these positions should be directed to graduate.studies@path.cam.ac.uk or 01223 333940.