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Department of Pathology

B Cell - James Edgar

Our Research

The immune system defends us against infections and cancer, but its excessive engagement can result in autoimmunity and allergy. The function of the immune system can also be suppressed in cancer and chronic infection, preventing immune-mediated clearance of disease. Our mission is to advance a fundamental understanding of the immune system in order to improve the diagnosis, prevention and treatment of individuals with infections, autoimmunity, allergy, and cancer.

The Division, led by Prof Klaus Okkenhaug, spans multiple research groups with interests in innate and adaptive immunity, cancer immunology, inflammation, and immunity at the foetal-maternal interface. Our research builds upon strengths in signal transduction, epigenetics and gene regulation, molecular biology and antigen processing and presentation. Research at the Division benefits from collaborations within the University of Cambridge and its affiliated institutions, Cambridge University Hospitals, and national and international collaborations with academic and industrial researchers.

Division Lead: Professor Klaus Okkenhaug

Our research groups

Professor Louise Boyle

Molecular mechanisms controlling peptide selection for immune recognition


Dr Andrew Conway Morris

Neutrophil biology, Host-microbe interactions, Critical illness and Sepsis, Pneumonia

Edgar Group

Aiming to understand endosome and exosome cell biology.

Dr Brian Ferguson

Innate immune signalling, anti-viral immunity, vaccinology


Dr Nick Holmes

The role of differentially spliced isoforms in regulating immune responses

Dr Adrian Kelly

Researching how Major Histocompatibility Complex (MHC) encoded molecules that play roles in these different antigen presentation pathways.

Dr Bidesh Mahata

Investigating immune cell-mediated steroidogenesis

McGovern Group

Researching the distinct properties of human macrophages and dendritic cells in both health and disease.

Professor Ashley Moffett

The question we are addressing is:  how does the maternal immune system regulate placentation in humans?

Okkenhaug Group

Focussing on how a group of enzymes, PI3Ks, are used by cells in the immune system to instruct & coordinate defense against pathogens.

Roychoudhuri Group

Aiming to uncover the molecular and cellular mechanisms underpinning immune regulation and cancer immunosuppression

Dr Andrew Sharkey

Underpinning immune regulation and cancer immunosuppression

Professor John Trowsdale

Interactions between polymorphic modulators of immunity