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Department of Pathology



Our Research 

The Liston-Dooley lab aims to understand the interaction of the immune system and the tissues during pathology and to exploit this understanding for therapeutic advantage.

In particular, we are currently focused on regulatory T cells in the tissues and the potential these anti-inflammatory cells have to control pathology during injury, autoimmunity and infection in key sites such as the brain and lung. The laboratory has extensive experience in mouse immunology, clinical immunology, immunogenetics, neuroimmunology, systems immunology, disease models, high-dimensional flow cytometry, and vector engineering.



Recent Publications


Lemaitre P, Tareen SH, Pasciuto E, Mascali L, Martirosyan A, Callaerts-Vegh Z, Poovathingal S, Dooley J, Holt MG, Yshii L, Liston A. Molecular and cognitive signatures of ageing partially restored through synthetic delivery of IL2 to the brain. EMBO Mol Med. 2023 Mar 28:e16805. doi: 10.15252/emmm.202216805. Epub ahead of print. PMID: 36975362.


Willemsen M, Barber JS, Nieuwenhove EV, Staels F, Gerbaux M, Neumann J, Prezzemolo T, Pasciuto E, Lagou V, Boeckx N, Filtjens J, De Visscher A, Matthys P, Schrijvers R, Tousseyn T, O'Driscoll M, Bucciol G, Schlenner S, Meyts I, Humblet-Baron S, Liston A. Homozygous DBF4 mutation as a cause of severe congenital neutropenia. J Allergy Clin Immunol. 2023 Feb 24:S0091-6749(23)00230-0. doi: 10.1016/j.jaci.2023.02.016. Epub ahead of print. PMID: 36841265.


Roca CP, Burton OT, Neumann J, Tareen S, Whyte CE, Gergelits V, Veiga RV, Humblet-Baron S, Liston A. A cross-entropy test allows quantitative statistical comparison of t-SNE and UMAP representations. Cell Rep Methods. 2023 Jan 13;3(1):100390. doi: 10.1016/j.crmeth.2022.100390. PMID: 36814837; PMCID: PMC9939422.


Whyte CE, Tumes DJ, Liston A, Burton OT. Do More with Less: Improving High Parameter Cytometry Through Overnight Staining. Curr Protoc. 2023 Jan;3(1):e678. doi: 10.1002/cpz1.678. Erratum for: Curr Protoc. 2022 Nov;2(11):e589. PMID: 36688737.


Hua Y, Vella G, Rambow F, Allen E, Martinez AA, Duhamel M, Takeda A, Jalkanen S, Junius S, Smeets A, Nittner D, Dimmeler S, Hehlgans T, Liston A, Bosisio FM, Floris G, Laoui D, Hollmén M, Lambrechts D, Merchiers P, Marine JC, Schlenner S, Bergers G. Cancer immunotherapies transition endothelial cells into HEVs that generate TCF1+ T lymphocyte niches through a feed-forward loop. Cancer Cell. 2023 Jan 9;41(1):226. doi: 10.1016/j.ccell.2022.12.006. Erratum for: Cancer Cell. 2022 Dec 12;40(12):1600-1618.e10. PMID: 36626867.


Liston A, Yshii L. T cells drive ageing of the brain. Nat Immunol. 2023 Jan;24(1):12-13. doi: 10.1038/s41590-022-01390-0. PMID: 36596892.




Principal Investigators











Professor Adrian Liston 














Dr James Dooley 
Principal Research Associate




Group Members


Oliver Burton

Senior Research Associate

Amy Dashwood

PhD student

Ntombizodwa Makuyana

PhD student

Václav Gergelits

Research Associate

Magda Ali

PhD student

Rafael Valente-Veiga

Research Associate

Omar Shabana

MPhil student

Arman Ghodsinia

PhD student

Marwan Achkir

Visiting student

Bolanle Olabiyi
Visiting Postdoctoral Researcher


Stavroula Piliou

PhD Student