Our Research
Each time a cell divides, it relies on critical systems to copy the genome and distribute these copies to daughter cells. Failure of these systems to operate correctly can result in cell death or genome instability. We are interested in developing new computational methods and software to study how these cell cycle mechanisms are designed and regulated. Understanding where, when, and why errors arise allow us to better understand how cells become cancerous, and it also puts us in a better position to purposely induce these errors to selectively target cancer cells and pathogens. Our research lies at the interface of biology, mathematics, and computer science and we employ methods from machine learning, software verification, bioinformatics, and computational modelling.
Our Current Projects include
DNAScent - Algorithms that detect replication fork movement in single molecules
Cancer Diganostics - Deep learning algorithms that debug cancer cells
Simulation and Verification - Programming languages that make simulations safe, fast, and easy
Key Publications
Boemo, M.A.†, Cardelli, L., Nieduszynski, C.A. (2020) The Beacon Calculus: A formal method for the flexible and concise modelling of biological systems. PLoS Computational Biology 16:e1007651. [bioRxiv] [DOI:10.1371/journal.pcbi.1007651]
Mueller, C.A.*, Boemo, M.A.*, Spingardi, P., Kessler, B. Kriaucionis, S. Simpson, J.T., Nieduszynski, C.A.† (2019) Capturing the dynamics of genome replication on individual ultra-long nanopore sequencing reads. Nature Methods 16:429-436. [bioRxiv][DOI:10.1038/s41592-019-0394-y]
Dr Michael Boemo
Principal Investigator
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Sarah Chapman PhD Student |
Dr Francisco Berkemeier Research Associate |
Dr Nishanthi Gangadharan Research Associate |
