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Department of Pathology

 
Read more at: Exploring the utility of X-ray tomography for virus research

Exploring the utility of X-ray tomography for virus research

12 April 2022

Most ultrastructural herpesvirus research is done using transmission electron microscopy—however, research led by Kamal Nahas and collaborators from Stephen Graham's Laboratory and Colin Crump's Laboratory has demonstrated that an emerging imaging technique, known as cryo-soft-X-ray tomography, could also be used and has a...


Read more at: Cambridge Festival: Germ Hide and Seek

Cambridge Festival: Germ Hide and Seek

6 April 2022

When germs such as viruses get into our bodies they often hide inside our cells. Our immune system is there to help you seek out pesky pathogens. In this challenge, your job is to be your immune system. Find the cells with germs hiding in the cells. Our researchers in the Boyle Lab have developed this fun game as part of...


Read more at: Event: DNA Tumour Virus 2022

Event: DNA Tumour Virus 2022

4 April 2022

Join us in Cambridge for DNA Tumour Virus 2022! The DNA Tumour Virus Meeting (DNA TVM) brings together a diverse group of researchers with shared research interests in the study of DNA tumour viruses. These viruses include the polyomaviruses, papillomaviruses, and adenoviruses which have proved to be invaluable models in...


Read more at: A new tool to clean, interpret and visualise aligned sequences

A new tool to clean, interpret and visualise aligned sequences

16 March 2022

Researchers at Pathology have devised a highly customisable command-line tool to clean, interpret and visualise multiple sequence alignments CIAlign effectively removes problematic regions and sequences from MSAs and provides novel visualisation options. This tool can be used to fine-tune alignments for further analysis...


Read more at: Researcher Spotlight: Nerea Irigoyen

Researcher Spotlight: Nerea Irigoyen

15 March 2022

Pathology researcher, Nerea Irigoyen, shares her experience contributing to the global pandemic research effort. In March 2020, at the start of the pandemic, Nerea had to postpone all her Zika research work. She took this opportunity to apply her work in reversing cell stress response to reduce virus replication to SARS-...


Read more at: How vaccinia virus tricks the immune system to escape antiviral defences

How vaccinia virus tricks the immune system to escape antiviral defences

7 January 2022

Jonas Dutra Albarnaz and Geoffrey L Smith Researchers from the Department of Pathology and the Gurdon Institute have uncovered a new mechanism by which pathogenic viruses antagonise our immune defences. Using molecular mimicry, the protein F14 from vaccinia virus (VACV) disables the immune response to inflammatory signals...


Read more at: Mayonnaise Miracle Babies

Mayonnaise Miracle Babies

25 November 2021

Ashley Moffett , Professor of Reproductive Immunology, has written a short-cut article in the London Review of Books on Mayonnaise Miracle Babies . In the article she writes about the development of immunosupressants and the problems of their use in women's reproductive health.


Read more at: What do parasites and plants have in common?

What do parasites and plants have in common?

28 October 2021

First front cover Catherine Merrick, Associate Professor in Parasitology, recently designed and published her first front cover for Trends in Parasitology ( April 2021 issue ). It accompanies the article 'Hypnozoites in Plasmodium : do parasites parallel plants?’ . This article also appeared in a Trends special collection...


Read more at: How herpes seizes proteins’ means of production
Many viruses use dedicated viral proteins that hijack host proteins, to reprogram a cell’s metabolism & produce copies of the virus. One such hijacker used by herpes simplex virus 1 can control not one, but many host’s proteins thanks to its flexibility

How herpes seizes proteins’ means of production

12 October 2021

Scientists at Cambridge and EMBL Hamburg have helped to reveal how the herpes simplex virus hijacks human proteins The Graham and Crump group s at the University of Cambridge and the Svergun Group at EMBL Hamburg have discovered a mechanism by which the herpes simplex virus takes control of the molecular machinery of human...


Read more at: The Chris Abell Postdoc Business Plan Competition

The Chris Abell Postdoc Business Plan Competition

26 March 2021

Do you have an idea worth a £20k investment? Our Postdoc Business Plan Competition has become a key annual event in the University’s entrepreneurial ecosystem and has spawned a number of successful spin-out companies. In 2020 the competition was renamed to honour the life and career of the late Chris Abell, Pro-Vice-...