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Researchers have mapped placental development from start to finish in a new study published in Nature. Using single-cell, spatial-omics, and multi-omics approaches creates an in-depth, high-resolution picture of how the placenta develops and communicates with the uterus. The research team, including Professor Ashley...

Dr Naomi McGovern of the Department of Pathology and the Centre for Trophoblast Research has been awarded a European Research Council (ERC) Consolidator Grant The grant will support PMDR: Placental macrophages: Their development and role in the placenta. My team’s research focus is human placental macrophage biology. We...

An IL-2 variant that is more tolerant of the acidic tumour environment improves immunotherapy in mice with melanoma. Researchers have created a variant of human IL-2 that can overcome challenges it experiences in the low-pH environment of tumours, boosting its ability to promote CD8 T cell and natural killer (NK) cell...

Natural killer (NK) cells are critical to immune surveillance against infections and cancer. Their role in immune surveillance requires that NK cells reside within tissues in a quiescent state. The mechanisms by which NK cells remain quiescent in tissues are incompletely understood. The transcriptional repressor BACH2...