Dr. Elise Kaplan

1. Antibiotic resistance & antibacterial targets

• Insights into bacterial lipoprotein trafficking from a structure of LolA bound to the LolC periplasmic domain E Kaplan, NP Greene & A Crow, V Koronakis. PNAS, 2018

• Antibiotic Resistance Mediated by the MacB ABC Transporter Family: A Structural and Functional Perspective NP Greene, E Kaplan, A Crow, V Koronakis. Frontiers in Microbiology, 2018

• Structure and mechanotransmission mechanism of the MacB ABC transporter superfamily A Crow & NP Greene, E Kaplan, V Koronakis. PNAS, 2017

• Kinetic characterization and molecular docking of novel allosteric inhibitors of aminoglycoside phosphotransferases N Leban, E Kaplan, L Chaloin, S Godreuil, C Lionne. Biochemica and Biophysica Acta (General Subjects), 2017

• Aminoglycoside binding and catalysis specificity of aminoglycoside 2″-phosphotransferase IVa: A thermodynamic, structural and kinetic study E Kaplan, JF Guichou, L Chaloin, S Kunzelmann, N Leban, EH Serpersu, C Lionne. Biochemica and Biophysica Acta (General Subjects), 2016

2. Control of actin polymerization

• Structure of CYRI-B (FAM49B), a key regulator of cellular actin assembly E Kaplan, R Stone, PJ Hume, NP Greene, V Koronakis. Acta D Crystallographica, 2020 

3. Azoreductases / Quinone Oxidoreductases

• Identification of NAD(P)H Quinone Oxidoreductase Activity in Azoreductases from P. aeruginosa: Azoreductases and NAD(P)H Quinone Oxidoreductases Belong to the Same FMN-Dependent Superfamily of Enzymes A Ryan, E Kaplan, JC Nebel, E Polycarpou, V Crescente, E Lowe, GM Preston, E Sim. PLoS One, 2014 

• Activation of nitrofurazone by azoreductases: multiple activities in one enzyme A Ryan, E Kaplan, N Laurieri, E Lowe, E Sim. Scientific reports, 2011

4. Stimulants of the CNS

• The effects of methylphenidate on cognitive performance of healthy male rats CL Rostron, E Kaplan, V Gaeta, R Nigriello, EJ Dommett. Frontiers in Neuroscience, 2013