Professor of Cell and Cancer Biology
Division of Cellular and Molecular Pathology
Project: Cell death and lineage commitment in mammary gland
Department of Pathology
University of Cambridge
Tennis Court Road
Cambridge
CB2 1QP
University of Cambridge
Tennis Court Road
Cambridge
CB2 1QP
Email:
cjw53@cam.ac.uk
Office Phone:
+44 (0)1223 333725
Websites:
Research themes
Division
Research Interests
- A mammary gland terminal end bud fluorescently stained with antibodies to the cell adhesion protein E-cadherin (green) and the marker of proliferation PCNA (red) with the nuclei of the cells in blue.
- Research Associates:
Sara Pensa, Timothy Sargeant, Bethan Lloyd-Lewis - Graduate Students:
Hayley Frend, Teresa Ho, Henrike Resemann, Matthew Wake,
Maximillian Blanck, Robert Hume
Key Publications
- Oliver, C.H., Khaled, W.T., Frend, H.T., Nichols, J. And Watson, C.J. (2012) The Stat6 regulated KRAB domain zinc finger protein Zfp157 regulates the balance of lineages in mammary gland and compensates for loss of Gata-3 (2012) Genes & Development. May 15;26(10):1086-97.
- Staniszewska AD, Pensa S, Caffarel MM, Anderson LH, Poli V, Watson CJ. (2012) Stat3 is required to maintain the full differentiation potential of mammary stem cells and the proliferative potential of mammary luminal progenitors. PLoS One 7(12):e52608.
- Hughes K, Wickenden JA, Allen JE, Watson CJ. (2012) Conditional deletion of Stat3 in mammary epithelium impairs the acute phase response and modulates immune cell numbers during post-lactational regression. J Pathol. May;227(1):106-17.
- Caffarel MM, Zaragoza R, Pensa S, Li J, Green AR, Watson CJ. (2012) Constitutive activation of JAK2 in mammary epithelium elevates Stat5 signalling, promotes alveologenesis and resistance to cell death, and contributes to tumourigenesis. Cell Death Differ. Mar;19(3): 511-22
- Kreuzaler, P.A., Staniszewska, A.D., Li, W., Omidvar, N., Kedjouar, B., Turkson, J., Poli, V., Flavell, R.A., Clarkson, R.W.E. and Watson, C.J. (2011) Stat3 controls lysosomal mediated cell death in vivo. Nature Cell Biology Mar;13(3):303-9.