Professor Suzanne D Turner

A full list of publications can be found via ORCID ID: https://orcid.org/0000-0002-8439-4507

1. Garland, G.D*., Ducray, S.P*., Jahangiri, L.J., Pucci, P., Burke, G.A.A., Monahan, J., Lai, R., Merkel, O., Schiefer, A., Kenner, L., Bannister, A.J. and Turner, S.D. (2022) BRG1 and NPM-ALK are co-regulated in Anaplastic Large Cell Lymphoma; BRG1 is a potential therapeutic target in ALCL. Cancers, in press
2. Lucy Hare, G.A. Amos Burke and Suzanne D. Turner (2021) Resistance to Targeted Agents Used to Treat Paediatric ALK-Positive ALCL 13(23), 6003; https://doi.org/10.3390/cancers13236003
3. Karaca-Atabay, E., Wang, Q., Cheong, T., Ambrogio, C., Mota, I., Prokoph, N., Leonardi, N., Hossa, J., Patrucco, E., Pich, A., Mologni, L., Gambacorti-Passerini, C., Brugières, L., Geoerger, B., Turner, S.D., Voena, C., & Chiarle, R. (2021) Tyrosine phosphatases regulate resistance to ALK inhibitors in lymphoma. Blood, in press
4. Newman, A.M., Zaka, M., Zhou, P., Blain, A.E., Erhorn, A., Barnard, A., Crossland, R.E., Wilkinson, S., Enshaei, A., De Zordi, J., Harding, F., Taj, M., Wood, K., Televantou, D., Genomic abnormalities of TP53 define distinct risk groups of paediatric B-cell non-Hodgkin lymphoma, Leukemia, in press
5. Gong, C., Krupka, J., Gao, J., Grigoropoulos, N.F., Screen, M., Cucco, F., Mohammed, M., Usheva, Z., Bornelöv, S., Ruiz De Los Mozos, I., Meng, W., Barrans, S., Bain, A., Burke, G.A., Forde, S., Matthews, J.D., Beer, P., Cooke, S., Burton, C., Campbell, P., Davies, A., Roman, E., Turner, S.D., Ule, J., Rand, V., Oellerich, T., Turner, M., Du, M., Samarajiwa, S. and Hodson, D.J. (2021) DDX3X and DDX3Y co-operate to facilitate MYC-driven B cell lymphomas. Molecular Cell, in press
6. Liang, H-C., Costanza, M., Prutsch, N., Zimmerman, M., Gurnhofer, E., Montes-Mojarro, I.A., Abraham, B.J., Prokoph, N., Stoiber, S., Tangermann, S., Lobello, C., Oppelt, J., Anagnostopoulos, I., Hielscher, T., Pervez, S., Klapper, W., Zammarchi, F., Silva, D.A., Garcia, K.C., Baker, D., Janz, M., Schleussner, N., Fend, F., Pospíšilová, S., Wallwitz, J., Stoiber, D., Simonitsch-Klupp, I., Cerroni, L., Pileri, S., de Leval, L., Sibon, D., Fataccioli, V., Gaulard, P., Assaf, C., Knörr, F., Damm-Welk, C., Woessmann, W., Turner, S.D., Look, A.T., Mathas, S*., Kenner, L*. and Merkel, O*. (2021) Super-enhancer-based identification of a BATF3/IL-2R−module reveals vulnerabilities in anaplastic large cell lymphoma. Nature Communications, in press
7. Ulferts, R., Marcassa, E., Timimi, L., Lee, L., Daley, A., Montaner, B., Turner, S.D., Florey, O., Baillie, K., Beale, R. (2021). Subtractive CRISPR screen identifies factors involved in non-canonical LC3 lipidation. BioRXIV Cell Reports, In press
8. Sangiorgio, V.F., Ruiz-Cordero, R., Vega, F.,  Feldman, A.L., Becker-Hecker, R., Evans, M.G., Clemens, M.W., Magno, W.B., Harris, H.L., Sohani, A., Sieling, B.A., Johnson, L., Macneill, F., O'donoghue, J., Patani, N., Televantou, D., Turner, S.D., Wotherspoon A., Young, K.H., Medeiros, L.J., and Miranda, R.N. (2021) EBV-Positive Lymphomas in Patients with Breast Implants: Another Subgroup with a Possible Etiologic Relationship to Breast Implants? Modern Pathology, doi: 10.1038/s41379-021-00863-1
9. Taj, M.M., Maecker-Kolhoff, B., Ling, R., Bomken, S., Burkhardt, B., Chiang, A.K.S., Csoka, M., Füreder, A., Haouy, S., Lazic, J., Miakova, N., Minard-Colin, V., Turner, S.D., Uyttebroeck, A. and Attarbaschi, A. on behalf of the European Intergroup for Childhood Non-Hodgkin Lymphoma (EICNHL) and the international Berlin-Frankfurt-Münster (i-BFM) Study Group (2021). Primary post-transplant lymphoproliferative disorder of the central nervous system: characteristics, management and outcome of 25 paediatric patients. British Journal of Haematology Jun;193(6):1178-1184. doi: 10.1111/bjh.17398
10. Mussolin L, Le Deley MC, Carraro E, Damm-Welk C, Attarbaschi A, Williams DM, Burke GAA, Horibe K, Nakagawa A, Wrobel G, Mann G, Csoka M, Uyttebroeck A, Delgado RF, Beishuizen A, Mellgren K, Burkhardt B, Klapper W, Turner SD, d’Amore ESG1, Lamant L, Reiter A, Woessmann W, Brugieres L, Pillon M, on behalf of the European Inter-Group for Childhood Non-Hodgkin lymphoma (EICNHL). (2020) Prognostic Factors in Childhood Anaplastic Large Cell Lymphoma: Updated Long Term Results of the International ALCL99 Trial. Cancers 12(10):2747. doi: 10.3390/cancers12102747.
11. Aksoy, O., Pencik, J., Hartenbach, M., Moazzami, A.A.,  Schlederer, M., Balber, T., Varady, A., Philippe, C., Baltzer, P., Mazumder, B., Mazumder, B., Whitchurch, J.B., Roberts, C.J., Haitel, A., Herac, M., Susani, M., Mitterhauser, M., Marculescu, R., Strangl-Kremser, J., Hassler, M., Kramer, G., Shariat, S.F., Turner, S.D., Tichy, B., Oppelt, J., Pospisilova, S., Hartenbach, S., Tangermann, S., Egger, G., Neubauer, H.A., Moriggl, R., Culig, Z., Greiner, G., Hoermann, G., Hacker, M., Heery, D.M., Merkel, O. and Kenner, L. (2020) Thyroid and androgen receptor signaling are antagonized by CRYM in prostate cancer. International Journal of Cancer, 148(3):731-747 (published in 2019 as a preprint BioRCiv doi: https://doi.org/10.1101/2019.12.19.881151)
12. Wim H. De Jong, Demosthenes Panagiotakos, Ana Proykova, Theodoros Samaras, Mark W. Clemens, Daphne De Jong, Ingrid Hopper, Hinne A. Rakhorst, Fabio Santanelli di Pompeo, Suzanne D. Turner; on behalf of SCHEER (2021) Final opinion on the safety of breast implants in relation to anaplastic large cell lymphoma: report of the Scientific Committee on Health, Emerging and Environmental Risks (SCHEER). Regulatory Toxicology and Pharmacology, Jun 30;125:104982. doi: 10.1016/j.yrtph.2021.104982
13. Leila Jahangiri, Tala Ishola, Perla Pucci, Ricky M. Trigg, Joao Pereira, John A. Williams, Megan L. Cavanagh, Georgios V. Gkoutos, Loukia Tsaprouni and Suzanne D. Turner (2021) The Role of Autophagy and lncRNAs in the Maintenance of Cancer Stem Cells. Cancers 13(6), 1239; https://doi.org/10.3390/cancers13061239
14. Turton, P., El-Sharkawi, D., Lyburn, I., Sharma, B., Mahalingam, P., Turner, S.D., MacNeil, F., Johnson, L., Hamilton, S., Burton, C. and Mercer, N. (2020) UK Guidelines on the Diagnosis and Treatment of Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL) on behalf of the Medicines and Healthcare products Regulatory Agency (MHRA) Plastic, Reconstructive and Aesthetic Surgery Expert Advisory Group (PRASEAG). European Journal of Surgical Oncology Feb;47(2):199-210. doi: 10.1016/j.ejso.2020.07.043, co-publication in British Journal of Haematology Feb;192(3):444-458. doi: 10.1111/bjh.17194 and Journal of Plastic and Reconstructive Surgery Jan;74(1):13-29. doi: 10.1016/j.bjps.2020.10.064
15. Okello, C.D., Niyonzima, N., Ferraresso, M., Kadhumbula, S., Ddungu, H., Tarlock, K., Balagadde, J., Omoding, A., Karagu, A., Mwaiselage, J., Harlan, J.M., Uldrick, T.S., Turner, S.D.* and Orem, J.* (2021) Review Series on Priorities in Haematological Care in Sub-Saharan Africa (SSA), Blood Cancers. Haematological Malignancies (HMs) in Sub-Saharan Africa (SSA): East Africa as an exemplar for Improving Care in the Region. Lancet Haematology, In press 
16. Deva, A.K., Turner, S.D, Kadin, M.E., Magnusson, M.R., Prince, H.M., Miranda, R.N., Inghirami, G.G. and Adams, W.P. (2020) Etiology of Breast Implant–Associated Anaplastic Large Cell Lymphoma (BIA-ALCL): Current Directions in Research. Cancers, Dec 21;12(12):3861. doi: 10.3390/cancers12123861 
17. Forde, S., Matthews, J.D., Jahangiri, L., Lee, L.C., Malcolm, T.I., Bell, N., Bomken, S., Burke, G.A.A., and Turner, S.D. (2020) Paediatric Burkitt lymphoma patient-derived xenografts capture disease characteristics over time and are a model for therapy, British Journal of Haematology,  http://dx.doi.org/10.1111/bjh.17043 
18. Prokoph, N., Probst, N.A., Lee, L.C., Monahan, J.M., Malik, V., Liang, H-C., Sharma, G.G., Montes-Mojarro, I., Mota, I., Larose, H., Forde, S.D., Imamoglu, R., Matthews, J.D., Trigg, R., Ceccon, M., Ducray, S.P., Lobello, C., Janikova, A., Gambacorti-Passerini, C., Pospisilova, S., Kenner, L., Klapper, W., Jauch, R., Woessmann, W., Chiarle, R., Mologni, L., Merkel, O., Brugières, L., Geoerger, B., Barbieri, I., and Turner, S.D. (2020) Inflammatory networks drive resistance to drugs in ALCL, ALK+; the IL10R is up-regulated in response to consistent exposure to ALK inhibition. Blood, In press 
19. Larose, H., Prokoph, N., Mian, S., Nuglozeh, E., Fazaludeen, F.M.S., Elmouna, A., Ashankyty, I., Mologni, L., Gambacorti-Passerini, C., Ming-Qing Du1, Hoefler, G., Pospisilova, S., Woessmann, W., Blundell, T., Ali., Damm-Welk, C., Fedorova, A., Lamant, L., Schlederer, M., Kenner, L., Merkel O. and Turner, S.D (2020) A novel mutation in Notch1 contributes to the pathogenesis of ALCL. Haematologica, in press 
20. Klingeberg, C., Kreutmair, S., Poggio, T., Keller, A., Andrieux, G., Miething, C., Follo, M., Pfeifer, D., Lengerke, C., Fend, F., Qintanilla de Fend, L., Zeiser, R., Turner, S.D., Boerries, M., Duyster, J. and Illert, A.L. (2019) Existence of reprogrammed lymphoma initiating cells in a murine ALCL model. Leukemia, in press 
21. Turner, S.D., Inghirami, G.I., Mirando, R.M. and Kadin, M (2019) Cell of origin and immunological events in the pathogenesis of BIA-ALCL. American Journal of Pathology, doi: 10.1016/j.ajpath.2019.09.005 
22. Trigg, R.M., Shaw, J.A. and Turner, S.D. (2019) Opportunities and challenges of circulating biomarkers in neuroblastoma. Open Biology, 9(5):190056. doi: 10.1098/rsob.190056 
23. Fritzal, F., Turner, S.D.* and Kenner, L.* (2019) Is Breast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL) a Hazard of Breast Implant Surgery? Open Biology, 9(4):190006. doi: 10.1098/rsob.190006 
24. Larose, H., Burke, G.A.A., Lowe, E. and Turner, S.D. (2019) From Bench to Bedside: The past, present and future of therapy for systemic paediatric ALCL, ALK+ British Journal of Haematology, doi: 10.1111/bjh.15763. 
25. Trigg, R.M.,* Lee, L.C.,* Prokoph, N.,* Jahangiri, L., Reynolds C.P., Burke, G.A.A., Probst, N.A., Han, M., Matthews, J.D., Lim, K.K., Manners, E., Martinez, S., Pastor, J., Blanco-Aparicio, C., Merkel, O., Garces de los Fayos Alonso, I., Kodajova, P., Tangermann, S., Högler, S., Luo, J., Kenner, L.* and Turner, S.D.* (2019) PIM1 inhibition enhances the sensitivity of high-risk aberrant  1 ALK-expressing neuroblastoma to ALK inhibition regardless of MYCN status. Nature Communications, DOI: 10.1038/s41467-019-13315-x
26. This publication was highlighted as an ‘editor’s choice’ in Science Translational Medicine: Joan Montero, (2019) A new hope for neuroblastoma treatment? Science Translational Medicine 11, 523, eaaz9769 DOI: 10.1126/scitranslmed.aaz9769
27. Haque, M., Li,J., Huang, Y-H., Almowaled, M., Barger, C.J., Karpf,A.R., Wang, P., Chen, W., Turner, S.D. and Lai, R. (2019) NPM-ALK is a key regulator of the oncoprotein FOXM1 in ALK-positive anaplastic large cell lymphoma: identification of a novel role for NPM1 in the pathobiology of NPM-ALK. Cancers, 11(8). pii: E1119. doi: 10.3390/cancers11081119
28. Prutsch, N., Suske, T., Liang, H.C., Wu, L., Simonitsch- Klupp, I., Alvarez-Hernandez, A., Gurnhofer, E., Schlederer, M., Roos, S., Kornauth, C., Leone, D., Aufinger, A., Hielscher, T., Aberger, F., Stoiber, D., Strobl, B., Müller, M., Jäger, U., Staber, P., Grebien, F., Moriggl, R., Inghirami, G., Sanda, T., Look, A.T., Turner, S.D., Kenner, L. and Merkel, O. (2018) Dependency on the TYK2/STAT1/MCL1 axis in Anaplastic Large Cell Lymphoma. Leukemia Mar;33(3):696-709. doi: 10.1038/s41375-018-0239-1. 
29. Schleussner, N., Merkel, O., Hummel, F., Costanza, M., Huan-Chang Liang, H-C., Romagnani, C., Durek, P., Anagnostopoulos, I., Hummel, M., Jöhrens, K., Niedobitek., A, Griffin, P.R., Woessmann, W., Damm-Welk, C., Hinze, C., Stoiber, D., Gillissen, B., Turner, S.D., Kaergel, E., von Hoff, L., Grau, M., Lenz, G., Dörken, B., Scheidereit, C., Kenner, L., Janz, M., and Mathas, S. (2017) The AP-1 -BATF and -BATF3 module is essential for growth, survival and TH17 / ILC3 skewing of anaplastic large cell lymphoma. Leukemia 32: 1994–2007 doi: 10.1038/s41375-018-0045-9 
30. Johnson, L., O’Donoghue, J.M., McLean, N., Turton, P., Khan, A.A., Turner, S.D., Lennard, A., Collis, N., Butterworth, M., Gui, G., Bristol, J., Hurren, J., Smith, S., Grover, K., Spyrou, G., Krupa, K., Azmy, I.A., Young, I.E., Staiano, H., Khalil J.J., and MacNeill, F.A. (2017) Breast Implant Associated Anaplastic Large Cell Lymphoma: The UK experience. Recommendations on its management and implications for informed consent. European Journal of Surgical Oncology Aug;43(8):1393-1401. doi: 10.1016/j.ejso.2017.05.004 
31. Hassler, M.R., Pulverer, W., Redl, E., Hacker, J., Garland, G., Schiefer, A., Simonitsch-Klupp, I., Kenner, L., Weinhäusel, A., Turner, S.D. and Egger, G. (2016) ALK-dependent transcription factor networks are associated with epigenomic alterations of DNA methylation in ALCL. Cell Reports 17(2):596-608. doi: 10.1016/j.celrep.2016.09.018 
32. Damm-Welk C., Fischer M., Narayanan V, Camidge R., Harris M., Siddiqi F., Burke G.A.A., Lehrnbecher T., Pulford K., Oschlies I., Siebert R., Turner SD* and Woessmann W*. (2016) Anti-ALK-antibodies in patients with ALK-positive malignancies not expressing NPM-ALK. Journal of Cancer, 7(11): 1383-1387. 
33. Malcolm, T., Hodson, D.J., Macintrye E.A. and Turner, S.D. (2016) Challenging perspectives on the cellular origin of lymphoma. Open Biology, 6(9). pii: 160232 
34. Malcolm, T*., Villarese, P*., Fairbairn, C., Lamant, L., Trinquand, A., Hook, C.E., Burke, G.A.A., Brugieres, L., Hughes K., Payet, D., Merkel, O., Schiefer, A., Ashankyty, I., Mian, S., Wasik, M., Turner, M., Kenner, L., Asnafi, V., Macintyre, E. and Turner, S.D. (2016) NPM-ALK mimics beta selection enabling thymic escape and peripheral lymphoma development. Nature Communications, 7, Article number: 10087 doi:10.1038/ncomms10087
35. Ceccon M., Boggio Merlo E., Mologni L., Poggio T., Varesio L.M., Menotti M., Bombelli S., Rigolio R., Manazza A.D., Ambrogio C., Giudici G., Casati C., Mastini C.,  Compagno M., Turner S.D., Gambacorti-Passerini C., Voena C. and Chiarle R. (2015) Excess of NPM-ALK oncogenic signaling promotes cellular apoptosis and drug dependency. Oncogene, doi: 10.1038/onc.2015.456 
36. Merkel, O., Hamacher, F., Griessl, R., Grabner, L., Schmatz, A., Prutsch, N., Baer, C., Hartmann, T., Simonitsch, I., Plass, C., Turner, S.D., Zenz, T., Greil, R. and Kenner, L. (2015) Oncogenic role of miR-155 in anaplastic large cell lymphoma lacking the t(2;5) translocation. J. Path Aug;236(4):445-56. doi: 10.1002/path.4539.
37. Turner, S.D., Lamant, L., Kenner, L. and Brugieres, L. (2015) Anaplastic Large Cell lymphoma: biology and clinical application. British Journal of Haematology, 173(3):560-72, doi: 10.1111/bjh.13958. 
38. Ye X., Shokrollahi K., Rozen W.M., Whitaker I.S.,* and Turner S.D.* (2014) Anaplastic Large Cell Lymphoma (ALCL) and Breast Implants: Breaking down the evidence *joint corresponding authors. Mutation Research – Reviews, 762C:123-132. 
39. Moti, N., Malcolm, T., Hamoudi, R., Mian, S., Garland, G., Hook, C.E., Burke, G.A.A., Wasik, M., Merkel, O., Kenner, L., Laurenti, E., Dick, J.E. and Turner, S.D. (2014) Anaplastic Large Cell Lymphoma stem cells possess a gene expression profile reflective of an early thymic progenitor pointing to a primitive cell of origin. Oncogene, Apr 2;34(14):1843-52. doi: 10.1038/onc.2014.112 
40. Laimer, D., Dolznig, H., Kollmann, K., Vesely, P.W., Schlederer, M., Merkel, O., Schiefer, A., Hassler, M.R., Heider, S., Amenitsch, L., Thallinger, C., Staber, P.B., Simonitsch-Klupp, I., Artaker, M., Lagger, S., Turner, S.D., Pileri, S., Piccaluga, P.P., Valent, P., Messana, K., Landra, I., Weichhart, T., Knapp, S., Shehata, M., Todaro, M., Sexl, V., Höfler, G., Piva, R., Medico, E., Riggeri, B.A., Cheng, M., Eferl, R., Egger, G., Penninger, J.M., Jaeger, U., Moriggl, R., Inghirami, G. and Kenner, L. (2012) Identification of PDGFR blockade as a rational and highly effective therapy for NPM-ALK driven lymphomas. Nature Medicine 18(11):1699-704 
41. Martinelli, P., Bonetti, P., Sironi, C., Pruneri, G., Fumagalli, C., Raviele, PR., Volorio, S., Pileri, S., Chiarle, R., Khoramian Tusi, B., McDuff, F.K.E., Turner, S.D., Inghirami, G., Pelicci, P.G. and Colombo, E. (2011) The lymphoma-associated NPM-ALK oncogene elicits a p16INKa/pRb-dependent tumour-suppressive pathway. Blood 117(24):6617-26. 
42. Merkel, O., Hamacher, F., Laimer, D., Scheideler, M., Trajanoski, Z., Egger, G., Turner, SD., Greil, R. and Kenner, L. (2010) Diacritic and functionally active microRNAs in both ALK+ and ALK- ALCL. PNAS 107(37):16228-33 
43. Youssif, C., Goldenbogan J., Hamoudi R., Viskaduraki M., Bacon, CM, Burke, A.A and Turner S.D. (2009) Genomic profiling of pediatric ALK-positive Anaplastic Large Cell Lymphoma – a Children’s Cancer and Leukaemia Group study. Genes Chromosomes and Cancer 48(11):1018-26 
44. Cui Y., Kerby A., McDuff F.K.E. and Turner S.D. (2009) NPM-ALK modulates the p53 tumour suppressor pathway in a JNK and PI 3-Kinase dependent manner: MDM-2 is a potential therapeutic target for the treatment of ALK-expressing malignancies. Blood. 113(21):5217-5227. 
45. Turner S.D., Yeung D., Hadfield K., Cook S.J. and Alexander D.R. (2007) The NPM- ALK Tyrosine Kinase Mimics TCR Signalling Pathways Inducing NFAT and AP-1 by Ras-Dependent Mechanisms. Cellular Signaling. 19(4):740-47.
46. Turner S.D., Tooze R.M., Macklennan K., Alexander D.R. (2003) Vav-promoter regulated oncogenic fusion protein NPM-ALK in transgenic mice causes B-cell lymphomas with hyperactive Jun kinase. Oncogene 22:7750-7761.