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Department of Pathology



Suzanne obtained her PhD from the world-renowned Paterson Institute for Cancer Research and the Christie Hospital in Manchester where she examined the potential toxic side-effects of chemoprotective gene therapy. This work was a collaborative effort with what was at that time the AstraZeneca Central Toxicology Labs at Alderley Edge.
Following this training period Suzanne moved to a research post at the Babraham Institute in Cambridge where under the guidance of Dr Denis Alexander she began to investigate mechanisms of Lymphomagenesis, a subject that she has pursued to become a world-expert in paediatric lymphomas, specifically Anaplastic Large Cell Lymphoma (ALCL). Since 2005, Suzanne has been leading an academic research group at the University of Cambridge within the Department of Pathology and based at the Addenbrooke’s Hospital campus in Cambridge. It is here that Suzanne conducts academic research of an international standard and also teaches and examines aspects of the medical, veterinary and natural science tripos. Suzanne is also director of teaching and deputy head of the Department of Pathology.

In 2007, Suzanne was awarded the prestigious Leukaemia and Lymphoma Research (LLR; now Blood Cancer UK) Bennett Fellowship and in 2012 a further 5-year LLR senior lectureship award. Amongst her achievements are the inception and establishment of the European Research Initiative on ALCL, a study group that brings together scientists from across Europe to foster collaboration and advancement in this important area of health research. Suzanne was also the lead of ‘ALKATRAS’, a European Union Marie Curie Innovative Training Network of 14 research groups in 7 EU countries and is currently non-clinical chair of the European Inter-Group for Collaboration into Childhood Non-Hodgkin Lymphoma (EICNHL), co-chair of the Cancer Research UK (CRUK) Cambridge Centre Paediatric Programme and biological lead for the National Cancer Research Institute (NCRI) paediatric lymphoma Clinical Study Group (CSG). Suzanne collaborates with a wide array of scientists and labs around the world, most notably the Uganda Cancer Institute in Kampala with whom she is working towards finding better therapies for children with cancer.

Amongst her other interests Suzanne is the scientific advisor to the Alex Hulme Foundation and Francesca Richardson Trust. She is also a member of both the American and British Associations for Cancer Research (BACR/AACR), the Children’s Cancer and Leukaemia Group (CCLG) in the UK and the International Society for Paediatric Oncology (SIOP). Suzanne also sits on the scientific committee of SIOP, the MHRA plastics, reconstructive and aesthetic surgery (PRASEAG) committee and the European Commission’s Scientific committee on Health, Environmental and Emerging Risks (SCHEER) working group on breast implants and cancer. In addition, she is a member of the international grant review panels of the World Cancer Research Fund and the Swedish Research Council’s medicine and health review panel.


Turner Research

In our lab, we investigate the pathogenesis and aetiology of paediatric cancers towards the development of biomarkers to facilitate kinder, less toxic and novel therapeutic approaches.

Mechanisms of Lymphomagenesis

Lymphoma is a heterogeneous disease class consisting of greater than 40 different sub-types and the incidence of this disease has been increasing year on year. In our research we are making progress towards understanding how and why lymphoma develops and hence in the development of new treatments. We investigate a paradigm of lymphomageneis in which a chromosomal translocation leads to the generation of an oncogene and subsequent presumed transformation of T-cells. The oncogene we work with is Nucleophosmin-Anaplastic Lymphoma Kinase (NPM-ALK), a hyperactive tyrosine kinase generated as a result of a translocation between chromosomes 2 and 5. This event is associated with greater than 90% of cases diagnosed as anaplastic large cell lymphoma (ALCL), a mature T-cell malignancy mainly occurring in paediatric patients. Our research aims to unravel the events leading from the t(2;5) to lymphoma. We use a variety of experimental approaches to reach this goal.

Understanding drug resistance in paediatric cancers

We are also developing a resource of patient derived xenografts of paediatric lymphoma, specifically ALCL and Burkitt lymphoma as well as neuroblastoma. Applying these models, our lab is conducting research to experimentally-induce relapse in an effort to understand clonal evolution of tumour cell growth. With this knowledge in hand, our lab then applies high-throughput drug screens and sequencing approaches to develop novel therapeutic regimens. Alongside, this research activity, we also employ CRISPR/Cas9 screens for the identification of putative mechanisms of drug resistance employing cell lines.

Comparative analysis of endemic and sporadic Burkitt lymphoma

Our lab works together with Jackson Orem at the Uganda Cancer Institute in Kampala, Uganda in an effort to understand the aetiology and pathogenesis of Burkitt lymphoma with a particular emphasis on tumour clonal evolution with treatment. This aspect of our research is supported by Cambridge Africa.

Breast implant associated anaplastic large cell lymphoma (BIA-ALCL)

The most recent addition to the family of ALCL is a form of cancer associated with the presence of textured breast implants. Given our 20 years of experience of working towards understanding the pathogenesis of ALCL, we have turned our attention to unraveling the mechanisms that drive this specific form of cancer.

Group Members:

  • Jamie Matthews 
  • Adiba Khan
  • Ana Canadas Garcia
  • Ali Hitchborn
  • Perla Pucci
  • Lucy Hare
  • Emily James
  • Gill Currie
  • Chris Steele
  • Carla Vazquez Amos
  • Rogier ten Hoopen
  • Marta Ferraresso
  • Leila Jahangiri
  • Aiindrila Dhara
  • Callum Malcolm
  • We collaborate with Dr Amos Burke, a paediatric oncologist based in Birmingham


Key publications: 

A full list of publications can be found via ORCID ID:

Auke Beishuizen*, Karin Mellgren*, Mara Andrés, Anne Auperin, Chris M. Bacon, Simon Bomke, G. A. Amos Burke, Birgit Burkhardt, Laurence Brugieres, Alan K.S. Chiang, Christine Damm-Welk, Emanuele d’Amore, Keizo Horibe, Edita Kabickova, Tasneem Khanam, Udo Kontny, Wolfram Klapper, Laurence Lamant, Marie-Cecile Le Deley, Jan Loeffen, Elizabeth Macintyre, Georg Mann, Friederike Meyer-Wentrup, Ulf Michgeh, Veronique Minard-Colin, Lara Mussolin, Ilske Oschlies, Catherine Patte, Marta Pillon, Alfred Reiter, Charlotte Rigaud, Leila Roncery, Itziar Salaverria, Ingrid Simonitsch-Klupp, Anne Uyttebroeck, Jaime Verdu-Amoros, Denise Williams, Wilhelm Woessmann, Andrew Wotherspoon, Grazyna Wrobel, Martin Zimmermann, Andishe Attarbashi* and Suzanne D. Turner* (2022) Improving outcomes of childhood and young adult non-Hodgkin lymphoma (NHL); twenty-five years of research and collaboration within the framework of the European Intergroup for Childhood Non-Hodgkin Lymphoma (EICNHL). Lancet Haematology 2023 10(3) 213-224 DOI:

Pucci P, Lee LC, Han M, Matthews JD, Jahangiri L, Schlederer M, Manners E, Sorby-Adams A, Kaggie J, Trigg RM, Steel C, Hare L, James ER, Prokoph N, Ducray SP, Merkel O, Rifatbegovic F, Luo J, Taschner-Mandl S, Kenner L, Burke GAA, Turner SD. Targeting NRAS via miR-1304-5p or farnesyltransferase inhibition confers sensitivity to ALK inhibitors in ALK-mutant neuroblastoma. Nat Commun. 2024 Apr 23;15(1):3422. doi: 10.1038/s41467-024-47771-x.

Nina Prokoph†, Jamie D. Matthews†, Ricky M. Trigg, Leila Jahangiri, Ivonne A. Montes-Mojarro, G.A. Amos Burke, Falko Fen, Olaf Merkel, Lukas Kenner, Birgit Geoerger, Robert Johnston, Matthew J. Murray, Charlotte Riguad, Laurence Brugières, and Suzanne D. Turner (2023) Patient-derived xenograft models of ALK+ ALCL reveal preclinical promise for therapy with Brigatinib. British Journal of Haematology, doi: 10.1111/bjh.18953

Jaques van Heerden, Joyce Balagadde-Kambugu, Racheal Angom, Rebecca Claire Lusobya, Guillermo Chantada, Laurence Desjardins, Ido Didi Fabia, Trijn Israels, Vivian Paintsil, Laila Hessissen, Mame Ndella Diouf, Moatasem Elayadi, Suzanne D. Turner, Francine Kouya and Jennifer A Geel (2022) Determining the baseline survival outcomes of the ‘six Global Initiative for Childhood Cancer index cancers’ in Africa. Paediatric Haematology and Oncology,

Okello, C.D., Niyonzima, N., Ferraresso, M., Kadhumbula, S., Ddungu, H., Tarlock, K., Balagadde, J., Omoding, A., Karagu, A., Mwaiselage, J., Harlan, J.M., Uldrick, T.S., Turner, S.D.* and Orem, J.* (2021) Review Series on Priorities in Haematological Care in Sub-Saharan Africa (SSA), Blood Cancers. Haematological Malignancies (HMs) in Sub-Saharan Africa (SSA): East Africa as an exemplar for Improving Care in the Region. Lancet Haematol. 2021 Oct;8(10):e756-e769. doi: 10.1016/S2352-3026(21)00198-8.

Forde, S., Matthews, J.D., Jahangiri, L., Lee, L.C., Malcolm, T.I., Bell, N., Bomken, S., Burke, G.A.A., and Turner, S.D. (2020) Paediatric Burkitt lymphoma patient-derived xenografts capture disease characteristics over time and are a model for therapy, British Journal of Haematology,

Prokoph, N., Probst, N.A., Lee, L.C., Monahan, J.M., Malik, V., Liang, H-C., Sharma, G.G., Montes-Mojarro, I., Mota, I., Larose, H., Forde, S.D., Imamoglu, R., Matthews, J.D., Trigg, R., Ceccon, M., Ducray, S.P., Lobello, C., Janikova, A., Gambacorti-Passerini, C., Pospisilova, S., Kenner, L., Klapper, W., Jauch, R., Woessmann, W., Chiarle, R., Mologni, L., Merkel, O., Brugières, L., Geoerger, B., Barbieri, I., and Turner, S.D. (2020) Inflammatory networks drive resistance to drugs in ALCL, ALK+; the IL10R is up-regulated in response to consistent exposure to ALK inhibition. Blood, 136(14):1657-1669. doi: 10.1182/blood.2019003793. Selected for a commentary written by the reviewer. Chosen for journal cover image

Larose, H., Prokoph, N., Mian, S., Nuglozeh, E., Fazaludeen, F.M.S., Elmouna, A., Ashankyty, I., Mologni, L., Gambacorti-Passerini, C., Ming-Qing Du1, Hoefler, G., Pospisilova, S., Woessmann, W., Blundell, T., Ali., Damm-Welk, C., Fedorova, A., Lamant, L., Schlederer, M., Kenner, L., Merkel O. and Turner, S.D (2020) A novel mutation in Notch1 contributes to the pathogenesis of ALCL. Haematologica, haematol.2019.238766. doi: 10.3324/haematol.2019.238766

Trigg, R.M.,* Lee, L.C.,* Prokoph, N.,* Jahangiri, L., Reynolds C.P., Burke, G.A.A., Probst, N.A., Han, M., Matthews, J.D., Lim, K.K., Manners, E., Martinez, S., Pastor, J., Blanco-Aparicio, C., Merkel, O., Garces de los Fayos Alonso, I., Kodajova, P., Tangermann, S., Högler, S., Luo, J., Kenner, L.* and Turner, S.D.* (2019) PIM1 inhibition enhances the sensitivity of high-risk aberrant ALK-expressing neuroblastoma to ALK inhibition regardless of MYCN status. Nature Communications, DOI: 10.1038/s41467-019-13315-x. This publication was highlighted as an ‘editor’s choice’ in Science Translational Medicine: Joan Montero, (2019) A new hope for neuroblastoma treatment?

Other publications: 


Turner, S.D. (2019) Anaplastic Large Cell Lymphoma: chapter in Non-Hodgkin Lymphoma in Childhood and Adolescence, Springer International Publishing DOI: 10.1007/978-3-030-11769-6, eBook ISBN: 978-3-030-11769-6, Hardcover ISBN: 978-3-030-11768-9

Final Opinion on the safety of breast implants in relation to anaplastic large cell lymphoma. SCHEER WG on the safety of breast implants in relation to anaplastic large cell lymphoma (BIA-ALCL). SCHEER members: Wim H De Jong (Chair), Demosthenes Panagiotakos (Rapporteur), Ana Proykova, Theodoros Samaras. External experts: Mark Clemens, Daphne De Jong, Ingrid Hopper, Hinne Rakhorst, Fabio Santanelli di Pompeo, Suzanne Turner. On request from: European Commission, Adopted on: 26 March 2021

Teaching and Supervisions

  1. Director of teaching, department of pathology, 2023-
  2. Organiser Part 1B Biology of Disease medical and veterinary science tripos/Natural sciences tripos (MVST/NST) course October 2014-2019 
  3. Cambridge University, Department of Pathology Natural Sciences Tripos Part II ‘modelling cancer in vivo
  4. Cambridge University, Department of Pathology Part 1B (second year) Biology of Disease course, cancer biology to ~450 students
  5. Lecture on paediatric cancer research to the MRes CRUK Cambridge cancer programme
  6. Organiser Part 1B histopathology practical classes October 2013-October 2015
  7. Leading and demonstrating the part 1B natural science tripos and MVST practicals and problem-solving exercises (histology based; immunology, cancer and other diseases), Cambridge University.
Research supervision: 

Current and past graduate students


Funding body/Course

Years of study

Position on leaving my lab

Aiindrila Dhara

EU Marie Curie Doctoral Network FANTOM



Ana Canada-Garcias

MPhil biological sciences



Ali Hazlewood

MPhil biological sciences



Callum Malcolm

CRUK Cambridge Centre



Carla Vasquez-Amos

EU Marie Curie Doctoral Network FANTOM



Charlotte Barrett

MPhil, self-funded


Research technician

Chris Steele

Departmental studentship



Alisha Burman

NIHR academic clinical fellow


Clinical training

Emily James




Lucy Hare

CRUK Cambridge Centre clinical PhD fellowship


Clinical training

Mun Liew



Postdoc in Hong Kong

Jamie Matthews

Alex Hulme Foundation PhD


Postdoc in Turner lab

Nina Prokoph



Postdoc at DKFZ German Cancer Research Center and Heidelberg University Hospital, Prof Marc-Steffan Raab and Niels Weinhold

Stephen Ducray



Strategy and Business Consulting for Bayer's R&D sector

Hugo Larose

Department Centenary Fund PhD Studentship


Pharmaceutical consulting

Sorcha Forde

Alex Hulme Foundation PhD


Pharmaceutical Consulting

Liam Lee



Merck – Director of medical affairs, oncology

Camilla Fairbairn



Postdoc., Black Belt Therapeutics (now BitBio)

Gavin Garland



Research Associate, MRC Toxicology Unit, Leicester, Prof Anne Willis (now Cambridge)

Timothy Malcolm



Postdoc., Kudos, Cambridge (now AstraZeneca)

Bola Hanna

MSc, University of Ulm, Germany


PhD, Heidelberg (now postdoc Harvard)

Naushad Moti*

Pakistani Higher Education Commission PhD


Research Associate, Duke-NUS, Singapore, Prof David Virshup (now flow cytometry manager, Australia)

Suzanne Rigby



Senior Scientist, Horizon Discovery (now executive lead immuno-oncology unit, GSK)

Fiona McDuff

Wellcome Trust PhD


Research Associate, University of Cambridge, Prof Gerard Evan (now owner of Fiona Patissiere)

Catrin Youssif

MSc, University of Vienna, Austria


PhD, Barcelona

Other Professional Activities


  1. Fellow Hughes Hall
  2. Executive committee member and co-lead paediatric programme, Cambridge Cancer Centre
  3. Coordinator FANTOM Marie Curie Doctoral Training Network (
  4. Coordinator ALKATRAS Marie Curie Innovative Training Network (
  5. Biological studies lead, NCRI paediatric lymphoma clinical studies sub-group
  6. Chair of the European Research Initiative for ALK-related malignancies (ERIA;
  7. Co-chair European Inter-group for Childhood Non-Hodgkin Lymphoma (EICNHL)
  8. Member the MHRA plastics, reconstructive and aesthetic surgery (PRASEAG) committee and the European Commission’s Scientific committee on Health, Environmental and Emerging Risks (SCHEER) working group on breast implants and cancer
  9. Member of the grant panel of the Swedish Research Council’s medicine and health review panel
  10. Member of the international grant panel of the World Cancer Research Fund
  11. Member of the scientific committee of the International Society for Paediatric Oncology (SIOP) 
  12. Scientific advisor to the Alex Hulme Foundation, Francesca Richardson Trust and Oncogene cancer research
  13. Chief scientific advisor to Melior Capital Management 2020-
  14. Invited member of the Continuous Update Project (CUP) mechanisms Expert Committee, Worldwide Cancer Research Fund Network, 1st February 2022 - 31st January 2025.
  15. American Association of Plastic Surgeons 2022 Expert Consensus Panel on BIA-ALCL, 2022
  16. Children’s Cancer and Leukaemia Group (CCLG) Biological Studies Steering Group (BSSG)
  17. Invited member of the University of Padova PhD collegium
  18. Member of the research advisory group of the children's cancer and leukaemia group
Professor of childhood cancer biology
Division of Cellular and Molecular Pathology

Contact Details

Division of Cellular and Molecular Pathology
Lab Block Level 3
Box 231
Addenbrooke's Hospital
Takes PhD students
Available for consultancy