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Department of Pathology

 

There is no evidence that vaccines drive any kind of process that results in cancer

News from this site - Mon, 08/09/2025 - 16:27

Professor Brian Ferguson has firmly rejected claims made at a Reform UK health conference suggesting Covid-19 vaccines could be linked to cancers in the royal family. Dr Aseem Malhotra, a cardiologist and guest speaker at the “Make Britain Healthy Again” event in Birmingham, alleged that mRNA vaccines may have been a...

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New protein-based tools boost fight against Oropouche virus

News from this site - Wed, 20/08/2025 - 15:10

Researcher Professor Stephen Graham has helped develop a suite of powerful protein-based tools that could transform the detection, study, and treatment of the Oropouche virus (OROV), a neglected tropical pathogen now linked to severe outbreaks and even fatalities. The study, published in EMBO Molecular Medicine , reports...

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New weakness uncovered in Ccancer-driving DNA circles

News from this site - Wed, 20/08/2025 - 11:57

A new study led by Pauline Pfuderer has revealed that extrachromosomal DNA (ecDNA) — rogue circular DNA fragments that fuel cancer growth and therapy resistance — replicate in a disorganised and fragile manner, leaving them highly vulnerable to stress during cell division. The research, published this month in Nucleic...

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Are aesthetic exosome treatments dangerous?

News from this site - Wed, 30/07/2025 - 13:12

In recent years, exosome therapy has emerged as a hot trend in the world of aesthetic medicine. Marketed as a regenerative, cutting-edge solution for anti-ageing, skin rejuvenation, hair restoration, and even scar reduction, exosome treatments are often pitched as a safer, more effective alternative to traditional cosmetic...

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Rethinking Immune Memory: New study reveals lymphocytes are more transient than we thought

News from this site - Wed, 09/07/2025 - 15:54

What if the immune system’s long-standing guards weren’t as stationary as we assumed? A groundbreaking new study by researchers from the University of Cambridge, Babraham Institute, and partners across Europe redefines our understanding of how immune cells inhabit our tissues—and challenges the idea of lifelong immune...

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Hope, Science, and Solidarity: A rare cancer community comes together

News from this site - Wed, 09/07/2025 - 11:04

On Friday, 27th June 2025, a unique and powerful gathering took place in Cambridge. For the first time, mothers, researchers, and a young adult patient—who had long supported each other online—came together in person to focus on a shared mission: improving the understanding and treatment of anaplastic large cell lymphoma (...

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Unlocking the Secrets of Scrub Typhus: Why Some Strains Are More Dangerous Than Others

News from this site - Fri, 04/07/2025 - 10:20

Scrub typhus, a severe and often life-threatening disease transmitted by mites, is caused by the intracellular bacterium Orientia tsutsugamushi . It's a major public health concern in parts of Asia, but despite its significance, the science behind why some strains cause deadly infections while others don’t has remained...

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Can We Predict Who Will Respond to COVID-19 Vaccines After an Organ Transplant?

News from this site - Thu, 03/07/2025 - 10:43

Spoiler: It’s complicated—but we're getting closer. A new study published in NPJ Vaccines by the Liston-Dooley Group took a deep dive into how solid organ transplant (SOT) recipients respond to COVID-19 mRNA vaccines—and what their immune systems might be telling us before they even get the shot. Why this matters: People...

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Unmasking HPV: How Gene Regulation Shapes the Battle Between Virus and Host

News from this site - Wed, 02/07/2025 - 13:23

Cervical cancer is a global health threat, and at the heart of its origin lies a microscopic agent: high-risk human papillomaviruses (HR-HPVs). But how do these viruses hijack our cells, and what causes their gene expression to spiral into cancer-causing chaos? Let’s explore the molecular tug-of-war between virus and host...

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P21 Activated Kinases: The Proteins That Control Cell Shape Without Lifting a Finger 

News from this site - Mon, 30/06/2025 - 11:55

A recent study published by the Koronakis Lab has revealed an unexpected finding. We usually think of proteins as little machines that need to be “switched on” to work. But in our recent study, we found something unexpected—some proteins can still affect cell behaviour even when they’re turned off. PAK proteins regulate...

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Professor Ming Du delivers annual Doniach Lecture

News from this site - Mon, 30/06/2025 - 11:02

Celebrating Professor Ming Du’s 2025 Doniach Lecture Last week, pathologists across the UK and Ireland gathered for the annual Doniach Lecture , one of the Pathological Society of Great Britain & Ireland’s flagship events. This year, we were honoured to welcome Professor Ming‑Qing Du as the distinguished recipient and...

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Balancing Breakthroughs and Bedtime: Adrian Liston on Science, Parenthood, and Equality

News from this site - Thu, 26/06/2025 - 13:07

When people imagine the life of a cutting-edge scientist, they might picture lab coats, late-night research, and groundbreaking discoveries. What they often don’t see is a toddler tugging at a parent’s sleeve or the careful calculus of who picks up the child from daycare. For Professor Adrian Liston, an immunologist at the...

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Cambridge researchers awarded Advanced Grants from the European Research Council

News - Tue, 17/06/2025 - 11:00

The successful Cambridge grantees’ work covers a range of research areas, including the development of next-generation semiconductors, new methods to identify dyslexia in young children, how diseases spread between humans and animals, and the early changes that happen in cells before breast cancer develops, with the goal of finding ways to stop the disease before it starts.

The funding, worth €721 million in total, will go to 281 leading researchers across Europe. The Advanced Grant competition is one of the most prestigious and competitive funding schemes in the EU and associated countries, including the UK. It gives senior researchers the opportunity to pursue ambitious, curiosity-driven projects that could lead to major scientific breakthroughs. Advanced Grants may be awarded up to € 2.5 million for a period of five years. The grants are part of the EU’s Horizon Europe programme. The UK agreed a deal to associate to Horizon Europe in September 2023.

This competition attracted 2,534 proposals, which were reviewed by panels of internationally renowned researchers. Over 11% of proposals were selected for funding. Estimates show that the grants will create approximately 2,700 jobs in the teams of new grantees. The new grantees will be based at universities and research centres in 23 EU Member States and associated countries, notably in the UK (56 grants), Germany (35), Italy (25), the Netherlands (24), and France (23).

“Many congratulations to our Cambridge colleagues on these prestigious ERC funding awards,” said Professor Sir John Aston, Cambridge’s Pro-Vice-Chancellor for Research. “This type of long-term funding is invaluable, allowing senior researchers the time and space to develop potential solutions for some of biggest challenges we face. We are so fortunate at Cambridge to have so many world-leading researchers across a range of disciplines, and I look forward to seeing the outcomes of their work.”

The Cambridge recipients of 2025 Advanced Grants are:

Professor Clare Bryant (Department of Veterinary Medicine) for investigating human and avian pattern recognition receptor activation of cell death pathways, and the impact on the host inflammatory response to zoonotic infections.

Professor Sir Richard Friend (Cavendish Laboratory/St John’s College) for bright high-spin molecular semiconductors.

Professor Usha Goswami (Department of Psychology/St John’s College) for a cross-language approach to the early identification of dyslexia and developmental language disorder using speech production measures with children.

Professor Regina Grafe (Faculty of History) for colonial credit and financial diversity in the Global South: Spanish America 1600-1820.

Professor Judy Hirst (MRC Mitochondrial Biology Unit/Corpus Christi College) for the energy-converting mechanism of a modular biomachine: Uniting structure and function to establish the engineering principles of respiratory complex I.

Professor Matthew Juniper (Department of Engineering/Trinity College) for adjoint-accelerated inference and optimisation methods.

Professor Walid Khaled (Department of Pharmacology/Magdalene College) for understanding precancerous changes in breast cancer for the development of therapeutic interceptions.

Professor Adrian Liston (Department of Pathology/St Catharine’s College) for dissecting the code for regulatory T cell entry into the tissues and differentiation into tissue-resident cells.

Professor Róisín Owens (Department of Chemical Engineering and Biotechnology/Newnham College) for conformal organic devices for electronic brain-gut readout and characterisation.

Professor Emma Rawlins (Department of Physiology, Development and Neuroscience/Gurdon Institute) for reprogramming lung epithelial cell lineages for regeneration.

Dr Marta Zlatic (Department of Zoology/Trinity College) for discovering the circuit and molecular basis of inter-strain and inter-species differences in learning

“These ERC grants are our commitment to making Europe the world’s hub for excellent research,” said Ekaterina Zaharieva, European Commissioner for Startups, Research, and Innovation. “By supporting projects that have the potential to redefine whole fields, we are not just investing in science but in the future prosperity and resilience of our continent. In the next competition rounds, scientists moving to Europe will receive even greater support in setting up their labs and research teams here. This is part of our “Choose Europe for Science” initiative, designed to attract and retain the world’s top scientists.”

“Much of this pioneering research will contribute to solving some of the most pressing challenges we face - social, economic and environmental,” said Professor Maria Leptin, President of the European Research Council. “Yet again, many scientists - around 260 - with ground-breaking ideas were rated as excellent, but remained unfunded due to a lack of funds at the ERC. We hope that more funding will be available in the future to support even more creative researchers in pursuing their scientific curiosity.”

Eleven senior researchers at the University of Cambridge have been awarded Advanced Grants from the European Research Council – the highest number of grants awarded to any institution in this latest funding round.

Westend61 via Getty ImagesScientist pipetting samples into eppendorf tube


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Congratulations on our success in the Academic Career Pathways Scheme

News from this site - Fri, 13/06/2025 - 09:53

We are thrilled to congratulate the following colleagues on their successful promotions under the University’s Academic Career Pathways (ACP) framework: Clinical Professorship Dr Catherine Elizabeth Hook , HO Promoted to Clinical Professor in recognition of her excellence in clinical/scientific work and honorary consultant...

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