Submitted by Livia Harriman on Fri, 28/07/2023 - 12:15
The Lulla research group has published a study on hotspots in neurotropic human astroviruses.
This study, led by Hashim Ali, has found "hotspots" in genomes of neurotropic human astroviruses that allow them to infect neurons.
It describes a molecular toolkit for studying non-classical human astroviruses, a family of viruses that are of zoonotic origin and are increasingly associated with neuropathology in humans.
Using this toolkit, authors identify the ‘hotspots’ in the virus genome where mutations allow the virus to grow in cell culture but remove its ability to infect neurons, which could be exploited for vaccine development.
Read the article here>> https://doi.org/10.1371/journal.pbio.3001815