News

First approved immunotherapy for melanoma triggers potent anti-tumour responses

2 December 2022

An IL-2 variant that is more tolerant of the acidic tumour environment improves immunotherapy in mice with melanoma. Researchers have created a variant of human IL-2 that can overcome challenges it experiences in the low-pH environment of tumours, boosting its ability to promote CD8 T cell and natural killer (NK) cell...

New MPhil in Biological Sciences

11 November 2022

The MPhil in Biological Sciences by Advanced Study is a full-time programme offering students the opportunity to undertake a period of study and lab-based research in an area of scientific importance and interest. Here at Pathology, we will be offering the Infection Biology and Molecular Immunology pathway. The COVID-19...

Roychoudhuri group identifies novel negative regulators of natural killer cell-mediated anti-metastatic immunity

26 October 2022

Natural killer (NK) cells are critical to immune surveillance against infections and cancer. Their role in immune surveillance requires that NK cells reside within tissues in a quiescent state. The mechanisms by which NK cells remain quiescent in tissues are incompletely understood. The transcriptional repressor BACH2...

Advancing clinical and translational research in germ cell tumours

26 October 2022

The Malignant Germ Cell International Consortium (MaGIC) has just published its recommendations set on advancing the field of germ cell tumours through integrative translational research, led by senior author Professor Matthew Murray from the Department of Pathology. The authors provide insights on how to address the...

How can poetry explore and share pathology research with the public?

11 October 2022

Podcast host Rebekah King speaks with David Cain and researchers at the University of Cambridge about their participation in the Creative Encounters Words programme. Listen now to researchers Dr Catherine Merrick (Senior Lecturer Pathology, Biological Sciences), Anne Thomas (Newnham College and Plant Sciences) and Mona...

Local immune recognition of trophoblast in early human pregnancy

4 October 2022

A new review published in Nature by Professor Ashley Moffett and Norman Shreeve focuses on the local interactions that occur early in pregnancy between placental trophoblast cells and maternal uterine immune cells. The cells which are crucial for healthy pregnancy are the subject of many questions and the role of the...

New insights into bacterial protein trafficking

7 September 2022

The Koronakis group has published a study that provides new insights into a protein trafficking system essential for the survival and pathogenicity of many bacteria. The work has the potential to aid the development of new antibiotics. Present in all bacteria, lipoproteins are anchored in the membrane by lipid chains and...

MRC Multimodal award for integrated human disease research

20 July 2022

The Medical Research Council (MRC) has awarded £7 million towards seven new collaborative research projects aiming to understand human diseases better. The complexities of human physiology mean that many components work within the body, across different scales (from molecules and cells to tissues, organisms and our...

What makes T cells sticky?

20 July 2022

A new publication sets out to figure out what makes T cells stick Many genetic and biochemical pathways are highly conserved in all living organisms. One such pathway is the so-called PI3K pathway, an ancient nutrient-sensing pathway found in worms, flies and humans. Its simplest manifestation involves three protein...

Prestigious European Research Council (ERC) Consolidator Grant awarded

15 June 2022

Dr Rahul Roychoudhuri and his team have been awarded the prestigious European Research Council (ERC) Consolidator Grant award Rahul and his team were awarded €1.8 million for their research aiming to break new ground in understanding how inflammatory responses are kept in check by regulatory T (Treg) cells...

First approved immunotherapy for melanoma triggers potent anti-tumour responses

New MPhil in Biological Sciences

Roychoudhuri group identifies novel negative regulators of natural killer cell-mediated anti-metastatic immunity

Advancing clinical and translational research in germ cell tumours

How can poetry explore and share pathology research with the public?

Local immune recognition of trophoblast in early human pregnancy

New insights into bacterial protein trafficking

MRC Multimodal award for integrated human disease research

What makes T cells sticky?

Prestigious European Research Council (ERC) Consolidator Grant awarded

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