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Department of Pathology

 
Virus gene expression mechanisms
RNA virus comparative genomics
Novel virus discovery
Ribosome profiling
Positive-sense RNA virus replication
Bioinformatics
RNA structure and function
Non-canonical translation mechanisms

Research

We are interested in the molecular biology of all sorts of RNA viruses (including both plant and animal). We are especially interested in studying the many weird and wonderful mechanisms that viruses use to express their genes, including discovering completely novel mechanisms of regulating gene expression. See our website: http://www.firthlab.path.cam.ac.uk/index.html

Publications

Key publications: 
  • Lulla V*, Firth AE* (2020) A hidden gene in astroviruses encodes a viroporin. Nat Commun 11:4070.
  • Lulla V*, Dinan AM, Hosmillo M, Chaudhry Y, Sherry L, Irigoyen N, Nayak KM, Stonehouse NJ, Zilbauer M, Goodfellow I, Firth AE* (2019) An upstream protein-coding region in enteroviruses modulates virus infection in gut epithelial cells. Nat Micro 4:280-292.
  • Napthine S, Ling R, Finch LK, Jones JD, Bell S, Brierley I*, Firth AE* (2017) Protein-directed ribosomal frameshifting temporally regulates gene expression. Nat Commun 8:15582.
  • Olspert A*, Carr JP, Firth AE* (2016) Mutational analysis of the Potyviridae transcriptional slippage site utilized for expression of the P3N-PIPO and P1N-PISPO proteins. Nucleic Acids Res 44:7618-7629.
  • Irigoyen N*, Firth AE*, Jones JD, Chung BY, Siddell SG, Brierley I* (2016) High-resolution analysis of coronavirus gene expression by RNA sequencing and ribosome profiling. PLoS Pathog 12:e1005473.
  • Olspert A, Chung BY, Atkins JF, Carr JP, Firth AE* (2015) Transcriptional slippage in the positive-sense RNA virus family PotyviridaeEMBO Rep 16:995-1004.
  • Smirnova E, Firth AE*, Miller WA*, Scheidecker D, Brault V, Reinbold C, Rakotondrafara AM, Chung BY, Ziegler-Graff V* (2015) Discovery of a small non-AUG-initiated ORF in poleroviruses and luteoviruses that is required for long-distance movement. PLoS Pathog 11:e1004868.
  • Firth AE* (2014) Mapping overlapping functional elements embedded within the protein-coding regions of RNA viruses. Nucleic Acids Res 42:12425-12439.
  • Fang Y*, Treffers EE, Li Y, Tas A, Sun Z, van der Meer Y, de Ru AH, van Veelen PA, Atkins JF, Snijder EJ*, Firth AE* (2012) Efficient -2 frameshifting by mammalian ribosomes to synthesize an additional arterivirus protein. Proc Natl Acad Sci U S A 109:E2920-E2928.
  • Jagger BW, Wise HM, Kash JC, Walters KA, Wills NM, Xiao YL, Dunfee RL, Schwartzman LM, Ozinsky A, Bell GL, Dalton RM, Lo A, Efstathiou S, Atkins JF, Firth AE*, Taubenberger JK*, Digard P* (2012) An overlapping protein-coding region in influenza A virus segment 3 modulates the host response. Science 337:199-204.
  • Loughran G, Firth AE*, Atkins JF (2011) Ribosomal frameshifting into an overlapping gene in the 2B-encoding region of the cardiovirus genome. Proc Natl Acad Sci USA 108:E1111-E1119.
  • Chung BY, Miller WA, Atkins JF, Firth AE* (2008) An overlapping essential gene in the PotyviridaeProc Natl Acad Sci USA 105:5897-5902.

Teaching and Supervisions

Teaching: 

Mathematical Biology 1A

Part II Pathology - Virology

Research supervision: 

Funding for our research comes from the Wellcome Trust, the European Research Council, and the Medical Research Council.

Research Associates (experimental virology): Dr Nina Lukhovitskaya, Dr Hazel Stewart, Dr Elizabeth Wignall-Fleming*

Research Associates (virus bioinformatics): Dr Katherine Brown, Dr Georgia Cook

Graduate Students: Ji Wang, Rhian O'Connor*, Samantha Thomas

* = joint with Lulla lab

Wellcome Trust Senior Research Fellow
Reader in Virus Bioinformatics
Division of Virology
Dr Andrew E. Firth

Contact Details

Department of Pathology
Division of Virology
University of Cambridge
Laboratories Block Level 5
Box 237, Addenbrookes Hospital
Hills Rd, Cambridge CB2 0QQ
United Kingdom
+44 (0)1223 762652
Not available for consultancy