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Dr Stephen Graham

Dr Stephen Graham

Sir Henry Dale Fellow and University Lecturer

Division of Virology

Molecular mechanisms of membrane trafficking and viral infection

Department of Pathology
University of Cambridge
Tennis Court Road
Cambridge
CB2 1QP

Office Phone: +44 (0)1223 336920

Research themes

Virology:

Molecular mechanisms of membrane trafficking and viral infection

Division

Virology:

Research Interests

Graham Research 2The compartmentalisation characteristic of eukaryotic cells presents a logistical dilemma: How do cells ensure components are efficiently delivered to only the correct intracellular compartment? My lab seeks to understand how multiprotein complexes regulate fusion of compartments in the eukaryotic endocytic pathway.

Viruses that seek to exploit the rich environment inside host cells face a similar dilemma: How can they subvert host membrane trafficking to ensure progeny virions efficiently exit infected cells? I am investigating how viruses that acquire double membrane envelopes within cells are trafficked to and fuse with the plasma membrane.

  • Group Members: 
    Susanna Colaco, Chen Gao, Tomasz Benedyk, Kaveesha Wijesinghe, Ben Butt, Kamal Nahas

Key Publications

  1. M.R. Hunter, G.G. Hesketh, T.H. Benedyk, A.C. Gingras, S.C. Graham (2018) Proteomic and biochemical comparison of the cellular interaction partners of human VPS33A and VPS33B. Journal of Molecular Biology, 430: 2153–2163
    doi: 10.1016/j.jmb.2018.05.019
  2. A. Albecka, D.J. Owen, L. Ivanova, J. Brun, R. Liman, L. Davies, M.F. Ahmed, S. Colaco, M. Hollinshead, S.C. Graham^ and C.M. Crump^ (2017) Dual function of the pUL7-pUL51 tegument protein complex in HSV-1 infection. Journal of Virology, 81: e02196-16
    doi: 10.1128/JVI.02196-16
  3. J. Muenzner, L.M. Traub, B.T. Kelly^, S.C. Graham^ (2017) Cellular and viral peptides bind multiple sites on the N-terminal domain of clathrin. Traffic, 18: 44–57
    doi: 10.1111/tra.12457
  4. S. Neidel, C. Maluquer de Motes, D.S. Mansur, P. Strnadova, G.L. Smith, S.C. Graham (2015) Vaccinia Virus Protein A49 is an Unexpected Member of the B-cell Lymphoma (Bcl)-2 Protein Family. Journal of Biological Chemistry, 290: 5991–6002
    doi: 10.1074/jbc.M114.624650
  5. B.T. Kelly, S.C. Graham, N. Liska, P.N. Dannhauser, S. Höning, E.J. Ungewickell, D.J. Owen (2014) AP2 controls clathrin polymerization with a membrane-activated switch. Science, 345: 459–463
    doi: 10.1126/science.1254836

(^Joint corresponding authors)