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Department of Pathology


Stephen is a University Professor in the Virology Division. His lab uses biochemical, biophysical and cell-based techniques to investigate the mechanisms by which viruses alter the infected cell environment. Specifically, he is interested in understanding how viruses change the composition and architecture of intracellular membranes, and how they evade immune recognition by the host. This research provides fundamental insights into virus biology and virus:host interactions that underpins the development of future anti-viral therapies and virus-based biologics. Stephen obtained his PhD in bacterial enzymology from the University of Sydney in 2006 before trading sunshine for drizzle with postdoctoral placements in Oxford (structural virology, 2006-9) and Cambridge (eukaryotic membrane trafficking, 2009-12).

Stephen is committed to providing a scientific training environment that is diverse, supportive and intellectually stimulating, helping all team members extend themselves and achieve to the best of their ability. In 2018 he collaborated with the Wellcome Trust as part of their Researcher Stories initiative, where he discussed building a reesarch team. Read the full article at the Wellcome Trust website or watch the video below.


Key publications: 
  1. N.S. Barbosa, J.O. Concha, L.L.P. da Silva, C.M. Crump^, S.C. Graham^ (2023) Oropouche virus glycoprotein topology and cellular requirements for glycoprotein secretion. Journal of Virology, 97: e01331-22 [doi: 10.1128/jvi.01331-22]
  2. T.H. Benedyk, V. Connor, E.R. Caroe, M. Shamin, D.I. Svergun, J.E. Deane, C.M. Jeffries, C.M. Crump, S.C. Graham (2022) Herpes simplex virus 1 protein pUL21 alters ceramide metabolism by activating the inter-organelle transport protein CERT. Journal of Biological Chemistry, 298: 102589 [doi: 10.1016/j.jbc.2022.102589]
  3. K.L. Nahas, V. Connor, K.M. Scherer, C.F. Kaminski, M. Harkiolaki^, C.M. Crump^, S.C. Graham^ (2022) Near-native state imaging by cryo-soft-X-ray tomography reveals remodelling of multiple cellular organelles during HSV-1 infection. PLoS Pathogens, 18: e1010629 [doi: 10.1371/journal.ppat.1010629]
  4. W.N.D. Gao, C. Gao, J.E. Deane, D.C.J. Carpentier, G.L. Smith, S.C. Graham (2022) The crystal structure of vaccinia virus protein E2 and perspectives on the prediction of novel viral protein folds. Journal of General Virology 103: 001716 [doi: 10.1099/jgv.0.001716]
  5. T.H. Benedyk, J. Muenzner, V. Connor, Y. Han, K. Brown, K.J. Wijesinghe, Y. Zhuang, S. Colaco, G.A. Stoll, O.S. Tutt, S. Svobodova, D.I. Svergun, N.A. Bryant, J.E. Deane, A.E. Firth, C.M. Jeffries, C.M. Crump^, S.C. Graham^ (2021) pUL21 is a viral phosphatase adaptor that promotes herpes simplex virus replication and spread. PLoS Pathogens, 17: e1009824 [doi: 10.1371/journal.ppat.1009824]
  6. C. Conceicao*, N. Thakur*, S. Human, J.T. Kelly, L. Logan, D. Bialy, S. Bhat, P. Stevenson-Leggett, A.K. Zagrajek, P. Hollinghurst, M. Varga, C. Tsirigoti, M. Tully, C. Chiu, K. Moffat, A.P. Silesian, J.A. Hammond, H.J. Maier, E. Bickerton, H. Shelton, I. Dietrich, S.C. Graham, D. Bailey (2020) The SARS-CoV-2 Spike protein has a broad tropism for mammalian ACE2 proteins. PLoS Biology 18: e3001016 [doi: 10.1371/journal.pbio.3001016]
  7. T.K. Soh*, C.T.R. Davies*, J. Muenzner*, L.M. Hunter, H.G. Barrow, V. Connor, C.R. Bouton, C. Smith, E. Emmott, R. Antrobus, S.C. Graham^, M.P. Weekes^, C.M. Crump^ (2020) Temporal Proteomic Analysis of Herpes Simplex Virus 1 Infection Reveals Cell-Surface Remodeling via pUL56-Mediated GOPC Degradation. Cell Reports, 33: 108235 [doi: 10.1016/j.celrep.2020.108235]
  8. B.G. Butt, D.J. Owen, C.M. Jeffries, L. Ivanova, C.H. Hill, J.W. Houghton, M.F. Ahmed, R. Antrobus, D.I. Svergun, J.J. Welch, C.M. Crump, S.C. Graham (2020) Insights into herpesvirus assembly from the structure of the pUL7:pUL51 complex. eLife, 9: e53789 [doi: 10.7554/eLife.53789]

 (*Joint first authors, ^Joint corresponding authors)

Professor of Virus:Host Interactions
Division of Virology
Dr Stephen  Graham

Contact Details

Department of Pathology
University of Cambridge
Tennis Court Road
+44 (0)1223 336920
Takes PhD students
Not available for consultancy