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Department of Pathology


Study finds testicular germ cell tumour cells release microRNA-containing extracellular vesicles that induce phenotypic and genotypic changes in cells of the tumour microenvironment

Testicular germ cell tumours (TCGTs) are characterised by overexpression of certain microRNAs, short non-coding RNAs that regulate gene expression by binding to mRNA molecules.

TCGT cells release these microRNAs into the bloodstream in extracellular vesicles (EVs).

Here, the authors showed that EVs released from the tumour cells can deliver microRNAs into cells of the tumour microenvironment, potentially contributing to tumour progression. The authors suggest that these microRNA-containing EVs could be useful as clinical biomarkers or potential therapeutic targets.'



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