Submitted by Livia Harriman on Wed, 31/05/2023 - 14:38
A new study of Salmonella bacteria finds the pathogen surprisingly restricts its uptake if a cell is already infected.
This self-limiting mechanism is due to effector-driven activation of N-WASP—the host actin regulator.
Salmonella causes various diseases in both humans and animals. Typically ingested through contaminated food, it causes acute inflammatory gastroenteritis but can also induce a more serious systemic disease.
The idea that an intracellular pathogen would restrict its uptake is at first glance surprising. However, for many viruses—including HIV, hepatitis, and influenza—once a cell is infected, further infection is inhibited, a phenomenon termed superinfection exclusion.
Restricting uptake in this way may ensure maximal resources for replication for the initially invading Salmonella and may also guarantee that more individual cells become infected.
Read the article Salmonella invasion of a cell is self-limiting due to effector-driven activation of N-WASP by Anthony Davidson, Peter J. Hume, Nicholas P. Greene, and Vassilis Koronakis in iScience,
Volume 26, Issue 5, 2023 here: https://doi.org/10.1016/j.isci.2023.106643
Authors
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Dr Peter Hume Research Associate |
Dr Nicholas Greene Research Associate |
Dr Anthony Davidson Research Associate |
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Professor Vassilis Koronakis Principal Investigator |
