skip to primary navigationskip to content

Erythropoiesis - Fbxo7 helps to stop cell division during red blood cell development

Research led by Drs Suzanne Randle and Heike Laman has been published in the Journal of Pathology this month. This work, funded by the BBSRC, identified a role for Fbxo7 in regulating the cell cycle during erythrocyte differentiation.

Blood Smear (Laman)During erythrocyte differentiation, Fbxo7 stabilised expression of the cell cycle inhibitor p27, and without correct regulation of these proteins, as demonstrated in mice lacking Fbxo7 protein, fewer red blood cells were produced, resulting in anaemia. In addition, Dr Randle was able to link this mechanism to recent genome wide association studies, which identified Fbxo7 as being associated with clinical red blood cell parameters in humans. This work identified a previously unknown and important function for Fbxo7 in red blood cell development

Advice for staff and students at the University and Colleges on novel coronavirus (COVID-19). The University is continually monitoring latest Public Health England and government advice about the virus.

Read more

Safe Space Information

In collaboration with the University Safe Space team, the department has generated a Return to the Workplace document that outlines the current social distancing measures which are in place to protect the safety and welfare of you and others. This document is updated frequently as guidance changes.