Research
Macrophages and dendritic cells play a key role in mediating tissue homeostasis. The laboratory researches the distinct properties of human macrophages and dendritic cells in both health and disease.
The focus of the laboratory is to understand the role of macrophages and dendritic cells within fetal membranes such as the placenta, and within reproductive organs such as the decidua.
Our approach integrates high dimensional techniques including single-cell RNA seq, advanced flow cytometry and confocal microscopy.
Group members:
Roksana Dutkiewicz (Research assistant)
Anna Appios (PhD candidate)
Jake Thomas (PhD candidate)
Dr. Joe Hutton (visiting scientist)
Publications
1. Human fetal dendritic cells promote prenatal T-cell immune suppression through arginase-2. McGovern N, et al. Nature (2017). PMID:28614294
2. Unsupervised High-Dimensional Analysis Aligns Dendritic Cells across Tissues and Species. McGovern N*, Guilliams M*, Dutertre CA*, et al. Immunity (2016). PMID:27637149
3. Human Dermal CD14+ Cells Are a Transient Population of Monocyte-Derived Macrophages. McGovern N*, Schlitzer A*, et al. Immunity (2014). PMID:25200712
4. A Three-Dimensional Atlas of Human Dermal Leukocytes, Lymphatics, and Blood Vessels. Wang XN, McGovern N, et al. Journal of Investigative Dermatology (2014). PMID:24352044
5. IRF4 transcription factor-dependent CD11b+ dendritic cells in human and mouse control mucosal IL-17 cytokine responses. McGovern N*, Schlitzer A*, et al. Immunity (2013). PMID:23706669
