Research
Understanding the role of Zika virus genome translation in viral pathogenicity and disease:
• Understanding how virus translation is regulated.
• Understanding the impact of changes in virus genome translation on virus virulence, disease and viral tropism.
Group members:
Eliza Walker (Harry Smith summer student)
César Palacios (Erasmus+ summer student)
Gema Martínez (Erasmus+ summer student)
Charlotte Lefèvre (Wolfson-Pathology PhD student)
Publications
1. Irigoyen, N., Dinan, AM., Meredith, LW., Goodfellow, I., Brierley, I., Firth, AE. The translational landscape of Zika virus during infection of mammalian and insect cells. (preprint; bioRxiv: doi:10.1101/112904).
2. Irigoyen, N., Dinan, AM., Brierley, I., Firth, AE. Ribosome profiling of the retrovirus murine leukemia virus. Retrovirology. 2018 Jan 22; 15(1):10.
3. Irigoyen, N., Firth, AE., Jones, JD., Chung, BY., Siddell, SG., Brierley, I. High-resolution analysis of coronavirus gene expression by RNA sequencing and ribosome profiling. PLoS Pathog. 2016 Feb 26; 12(2):e1005473
