News

Vaccinia Virus Protein C6 Is a Virulence Factor that Binds TBK-1 Adaptor Proteins and Inhibits Activation of IRF3 and IRF7

13 December 2013

08 September 2011 Dr Rebecca Sumner and Prof Geoffrey Smith have collaborative paper published in PLoS Pathogens. Read more

Sticky/Citron kinase maintains proper RhoA localization at the cleavage site during cytokinesis

13 December 2013

17 November 2013 Dr Paolo D’Avino’s group published in The Journal of Cell Biology about the regulation of the small RhoA GTPase during cytokinesis. This study originates from the long-standing interest of Dr D’Avino in the mechanisms that control the last phase of cell division, cytokinesis. The first author of the paper...

Deregulation of the serum- and glucocorticoid-inducible kinase SGK1 in the endometrium causes reproductive failure

13 December 2013

09 November 2011 Dr Andrew Sharkey is a co-author of a paper published in Nature Medicine. The Nature Medicine paper resulted from a long term collaboration between Andrew Sharkey and the group headed by professor Jan Brosens at Imperial, who is the senior author of the study. This work was based on earlier findings made...

Herpes Simplex Virus-1 Transactivator Infected Cell Protein-4 Drives VEGF-A Dependent Neovascularization

12 December 2013

6 October 2011 The Herpes Simplex Virus-1 Transactivator Infected Cell Protein-4 Drives VEGF-A Dependent Neovascularization. Dr Stacey Efstathiou has collaborative paper published in PLoS Pathogens. Transmission Electron Microscopy image of Herpes simplex virus type 1 Courtesy of Dr Colin Crump. Read more

Out of Africa: what is an allergen?

12 December 2013

9 January 2011 Some fundamental questions in allergy remain unanswered. Among them are ‘What exactly is an allergen?’ and ‘Why is the immune response so similar to that against parasitic worms?’ Trust-funded researchers are examining the problems through an evolutionary lens. By Penny Bailey Film lovers will be familiar...

New mechanism to control the actin cytoskeleton of the mammalian cell

12 December 2013

8 August 2011 Animal and plant cells contain a dynamic network of actin filaments, which are assembled and disassembled to drive fundamental processes such as cell migration, phagocytosis, synapse plasticity and tissue repair, and also pathologies like tumour and pathogen invasion. Prof Vassilis Koronakis and colleagues...

Common gene fault triggers more aggressive cervical cancer

12 December 2013

19 May 2011 Common gene fault triggers a ripple of molecular signals leading to more aggressive cervical cancer . Cancer Research UK scientists have discovered that a common gene fault in cervical cancer cells triggers a ripple of molecular signals - which makes the disease more aggressive, according to research published...

10,000th structure curated by the Protein Data Bank in Europe

12 December 2013

4 February 2011 The Protein Data Bank in Europe (PDBe) has annotated its 10 000th structure for inclusion in the Protein Data Bank (PDB), a freely available resource for life science researchers. Gerard Kleywegt, Head of PDBe, tells us about the project and what's special about this milestone structure. PDBe is part of the...

Researchers Publish Breakthrough in Understanding Cancer Cell Death

12 December 2013

22 February 2011 Pathology researchers publish in Nature Cell Biology exciting breakthrough for the understanding of cell death and the treatment of cancers that are resistant to cell death . The work was carried out primarily by two PhD students in Christine Watson’s lab; the first author Peter Kreuzaler was funded by a...

Department researchers Reveal How Membrane Efflux Pumps Open To Confer Multidrug Resistance and Virulence on Bacteria

12 December 2013

21 January 2011 Department researchers reveal in PNAS how membrane efflux pumps open to confer multidrug resistance and virulence on bacteria. Published this month: Pei X-Y, Hinchliffe P, Symmons M, Koronakis E, Hughes C, Koronakis V (2011) Structures of sequential open states in a symmetrical opening transition of the...

Vaccinia Virus Protein C6 Is a Virulence Factor that Binds TBK-1 Adaptor Proteins and Inhibits Activation of IRF3 and IRF7

Sticky/Citron kinase maintains proper RhoA localization at the cleavage site during cytokinesis

Deregulation of the serum- and glucocorticoid-inducible kinase SGK1 in the endometrium causes reproductive failure

Herpes Simplex Virus-1 Transactivator Infected Cell Protein-4 Drives VEGF-A Dependent Neovascularization

Out of Africa: what is an allergen?

New mechanism to control the actin cytoskeleton of the mammalian cell

Common gene fault triggers more aggressive cervical cancer

10,000th structure curated by the Protein Data Bank in Europe

Researchers Publish Breakthrough in Understanding Cancer Cell Death

Department researchers Reveal How Membrane Efflux Pumps Open To Confer Multidrug Resistance and Virulence on Bacteria

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