Department of Pathology

The Department of Pathology is one of the largest Departments in the School of Biological Sciences, and a leading research institution with a yearly research income of £9M. The Department's research seeks to understand - and so ultimately arrest and reverse - disease processes of medical and social significance. The work of the Department is organised into five Divisions: Cell and Molecular Pathology, Immunology, Microbiology and Parasitology, Virology and Molecular Histopathology, split between the University site and Addenbrooke's Hospital, as well as undertaking cross-disciplinary research with colleagues at Research Institutes including the Cambridge Institute for Medical Research and the Hutchison-MRC Institute for Cancer Research.

The Department also has a major yearly commitment in the teaching and training to over 800 undergraduate students of medicine and of veterinary and natural science. In its research laboratories it provides training for over 70 graduate students. Members of the Department also contribute, together with colleagues in the National Health Service and Health Protection Agency, to provision of diagnostic services within Addenbrooke's Hospital and the Anglia Region.

Latest talks ...
Wed 22 Oct 12:30 PM
Professor Veit Hornung, University of Bonn, Germany
Wed 22 Oct 3:00 PM
Haploid Genetic Screens in Human Cells to Identify Disease-relevant Genes
Dr Thijn Brummelkamp: Netherlands Cancer Institute
Thu 23 Oct 12:00 PM
Regulation of hepatitis C virus by liver-specific microRNA-122
Dr Catherine Jopling, School of Pharmacy, University of Nottingham, UK
Fri 24 Oct 1:00 PM
The human leukaemia virus HTLV-1: clonality, latency and immune response.
Prof. Charles Bangham ( Imperial College London)
News and Events

Milk kills - milk fatty acids permeabilize lysosomes to induce cell death

Following lactation, milk-producing mammary epithelial cells are removed by an exquisitely controlled process of cell death. Having previously demonstrated that the transcription factor Stat3 regulates a lysosomal-mediated programme of cell death (LM-PCD) during mammary gland involution, Tim Sargeant and Bethan Lloyd-Lewis in Christine Watson’s lab report this week in Nature Cell Biology the mechanism that controls the release of lysosomal cathepsins to initiate cell death. More

Stat3 controls cell death during mammary gland involution by regulating uptake of milk fat globules and lysosomal membrane permeabilization. Sargeant TJ, Lloyd-Lewis B, Resemann HK, Ramos-Montoya A, Skepper J, Watson CJ. Nat Cell Biol. 2014 Oct 5. doi: 10.1038/ncb3043.