Department of Pathology

The Department of Pathology is one of the largest Departments in the School of Biological Sciences, and a leading research institution with a yearly research income of £9M. The Department's research seeks to understand - and so ultimately arrest and reverse - disease processes of medical and social significance. The work of the Department is organised into five Divisions: Cell and Molecular Pathology, Immunology, Microbiology and Parasitology, Virology and Molecular Histopathology, split between the University site and Addenbrooke's Hospital, as well as undertaking cross-disciplinary research with colleagues at Research Institutes including the Cambridge Institute for Medical Research and the Hutchison-MRC Institute for Cancer Research.

The Department also has a major yearly commitment in the teaching and training to over 800 undergraduate students of medicine and of veterinary and natural science. In its research laboratories it provides training for over 70 graduate students. Members of the Department also contribute, together with colleagues in the National Health Service and Health Protection Agency, to provision of diagnostic services within Addenbrooke's Hospital and the Anglia Region.

Latest talks ...
Thu 27 Nov 12:00 PM
Structural insights on cell entry of enveloped RNA viruses and the antiviral activities of viperin
Dr Yorgo Modis, Department of Medicine, University of Cambridge, UK
Fri 28 Nov 1:00 PM
Lymphocyte population dynamics and genetic susceptibility to autoimmune disease
Rose Zamoyska, University of Edinburgh
Wed 03 Dec 12:30 PM
Responses of mesenchymal stromal cells to hypoxia
Professor Rhodri Ceredig, National University of Ireland, Galway
Thu 04 Dec 12:00 PM
HIV and Cell Autonomous Innate Immunity: Going under the radar
Prof. Greg Towers, Division of Infection and Immunity, University College London, UK
News and Events

Cancer cell fingerprints in the blood may speed up childhood cancer diagnosis

Newly-identified cancer cell fingerprints in the blood could one day help doctors diagnose a range of children's cancers faster and more accurately.

Reaearch lead by Dr Matthew Murray and Professor Nicholas Coleman has uncovered the fingerprints left by the tumours by analysing blood samples from children when they were diagnosed with cancer. Read more

Milk kills - milk fatty acids permeabilize lysosomes to induce cell death

Following lactation, milk-producing mammary epithelial cells are removed by an exquisitely controlled process of cell death. Having previously demonstrated that the transcription factor Stat3 regulates a lysosomal-mediated programme of cell death (LM-PCD) during mammary gland involution, Tim Sargeant and Bethan Lloyd-Lewis in Christine Watson’s lab report this week in Nature Cell Biology the mechanism that controls the release of lysosomal cathepsins to initiate cell death. Read more

Stat3 controls cell death during mammary gland involution by regulating uptake of milk fat globules and lysosomal membrane permeabilization. Sargeant TJ, Lloyd-Lewis B, Resemann HK, Ramos-Montoya A, Skepper J, Watson CJ. Nat Cell Biol. 2014 Oct 5. doi: 10.1038/ncb3043.