Department of Pathology

The Department of Pathology is one of the largest Departments in the School of Biological Sciences, and a leading research institution with a yearly research income of £9M. The Department's research seeks to understand - and so ultimately arrest and reverse - disease processes of medical and social significance. The work of the Department is organised into five Divisions: Cell and Molecular Pathology, Immunology, Microbiology and Parasitology, Virology and Molecular Histopathology, split between the University site and Addenbrooke's Hospital, as well as undertaking cross-disciplinary research with colleagues at Research Institutes including the Cambridge Institute for Medical Research and the Hutchison-MRC Institute for Cancer Research.

The Department also has a major yearly commitment in the teaching and training to over 800 undergraduate students of medicine and of veterinary and natural science. In its research laboratories it provides training for over 70 graduate students. Members of the Department also contribute, together with colleagues in the National Health Service and Health Protection Agency, to provision of diagnostic services within Addenbrooke's Hospital and the Anglia Region.

Latest talks ...
Thu 30 Oct 12:30 PM
Myeloid lineage switch in pro-B cells generates novel M phi subsets during homeostasis & inflammation
Professor Derek Gilroy, University College London
Fri 31 Oct 1:00 PM
Leukocyte migration and gradient sensing in vivo: lessons from zebrafish
Milka Sarris, Department of Physiology, Development and Neuroscience
Wed 05 Nov 12:30 PM
The IL-6 cytokine family and CD4+ T cell response during acute and chronic viral infections
Dr James Harker, Imperial College London
Thu 06 Nov 12:00 PM
RNA virus evolution in vitro and in vivo: Monitoring and predicting evolutionary trajectories
Dr Marco Vignuzzi, Viral Populations and Pathogenesis Unit, Institut Pasteur, France
News and Events

Milk kills - milk fatty acids permeabilize lysosomes to induce cell death

Following lactation, milk-producing mammary epithelial cells are removed by an exquisitely controlled process of cell death. Having previously demonstrated that the transcription factor Stat3 regulates a lysosomal-mediated programme of cell death (LM-PCD) during mammary gland involution, Tim Sargeant and Bethan Lloyd-Lewis in Christine Watson’s lab report this week in Nature Cell Biology the mechanism that controls the release of lysosomal cathepsins to initiate cell death. More

Stat3 controls cell death during mammary gland involution by regulating uptake of milk fat globules and lysosomal membrane permeabilization. Sargeant TJ, Lloyd-Lewis B, Resemann HK, Ramos-Montoya A, Skepper J, Watson CJ. Nat Cell Biol. 2014 Oct 5. doi: 10.1038/ncb3043.