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Gene discovery helps explain how flu can cause severe infections

last modified Dec 17, 2013 10:10 AM

19 July 2012

Scientists have discovered a new gene in the influenza virus that helps the virus control the body's response to infection.

Although this control is exerted by the virus, surprisingly it reduces the impact of the infection. The findings will help researchers better understand how flu can cause severe infections, as well as inform research into new treatments. Researchers found when the virus gene - called PA-X - was active, mice infected with flu subsequently recovered. When the PA-X gene did not work properly, the immune system was found to overreact. This made the infection worse, and did not help destroy the virus any quicker.

The study looked at how the gene affected the behaviour of "Spanish flu", a virulent strain of influenza that caused a pandemic in 1918. It was carried out by the Universities of Cambridge, Cork, Edinburgh and Utah, the Institute of Systems Biology in Seattle and the United States National Institutes of Health. Scientists discovered the PA-X gene some 30 years after flu genome was first decoded.

The researchers include Dr Andrew Firth of the Department of Pathology, University of Cambridge, Professor Paul Digard of The Roslin Institute at the University of Edinburgh, and formerly of the Department of Pathology Cambridge, and Drs Brett Jagger and Helen Wise, also formerly of the Department of Pathology Cambridge. Dr Andrew Firth said: "The flu virus has a very, very small genome - just 12 genes. Finding a new gene makes a pretty significant change to our understanding of this virus." The research was funded by the Biotechnology and Biological Sciences Research Council, the Medical Research Council, the U. S. National Institutes of Health, Science Foundation Ireland, and the Wellcome Trust.


B. W. Jagger, H. M. Wise, J. C. Kash, K.-A. Walters, N. M. Wills, Y.-L. Xiao, R. L. Dunfee, L. M. Schwartzman, A. Ozinsky, G. L. Bell, R. M. Dalton, A. Lo, S. Efstathiou, J. F. Atkins, A. E. Firth, J. K. Taubenberger, and P. Digard. An Overlapping Protein-Coding Region in Influenza A Virus Segment 3 Modulates the Host Response. Science 337:199-204. [DOI:10.1126/science.1222213]