skip to content

Department of Pathology

 

Research in the Department is arranged into four divisions for the purposes of grouping various research themes and teaching activities.

Cellular and Molecular Pathology

Division Head: Professor Nick Coleman

Group Leaders

Research

Apoptosis and cell injury, chromosomal abnormalities, papillomavirus carcinogenesis and vaccine development, tissue regeneration, angiogenesis, cell signalling, genomics, and stem cell biology. Virus and host mechanisms in cervical carcinogenesis, epigenetic determinants of human papillomavirus oncogene expression, molecular pathology of lymphoma, mechanisms of lymphomagenesis, Wnt pathway signalling in colorectal cancer, bowel cancer screening, non-coding RNAs in malignant germ cell tumours, novel genetic markers for blood-based monitoring of childhood cancers

Teaching

Aspects of Cellular Molecular Pathology are taught in the 2nd year (Part IB) and the 3rd year (Part II) courses in Pathology and in the Postgraduate Education Programme. The Division organises clinical pathology teaching in the Cambridge clinical course.

Lab Managers: Anna Rudd (Tennis Court Road) and Nadine Law (Addenbrooke's Biomedical Campus)

Contact: sec.cmp@path.cam.ac.uk

Immunology

Division Head: Professor Klaus Okkenhaug

Group Leaders

Research

Immunity and infection, autoimmune disease, cell signalling, cancer immunotherapy, immunology in pregnancy; immunogenetics; natural killer cell biology, antigen presentation, antibody structure and function.

Teaching

Aspects of Immunology are taught in the 2nd year (Part IB) and the 3rd year (Part II) courses in Pathology and in the Postgraduate Education Programme.

Lab Manager: Anna Rudd

Contact: sec.imm@path.cam.ac.uk

Microbiology and Parasitology

Division Head: Katerina Artavanis-Tsakonas

Group Leaders

Research

Bacterial motility and flagellar biogenesis; mechanisms of entry of bacteria into mammalian cells, bacterial toxin export and multi-drug efflux, regulation of gene expression during host-pathogen interaction; transmission, cell-cycle dynamics and virulence mechanisms in malaria parasites; host modulation by parasitic organisms; dynamics of parasitic worm infection in human populations.

Teaching

Aspects of Microbiology and Parasitology are taught in the 2nd year (Part IB) and the 3rd year (Part II) courses in Pathology and in the Postgraduate Education Programme.

Lab Manager: Anna Rudd

Contact: sec.mpd@path.cam.ac.uk

Virology

Division Head: Professor Ian Brierley

Group Leaders

Research

The topics of research on RNA viruses include the replication mechanisms of influenza A virus (te Velthuis), virus discovery and evolution (Firth), the molecular biology of noroviruses, flaviviruses and other positive strand RNA viruses (Goodfellow, Sweeney, Irigoyen) and the translational control of RNA virus and host gene expression (Brierley, Firth and Sweeney). Research on DNA viruses includes the replication, pathogenesis and immunobiology of vaccinia virus (Smith), herpesvirus and polyomavirus assembly and egress (Crump, Graham), the structural biology of virus proteins involved in pathogenesis and replication (Graham) and the pathogenesis of human papillomavirus infections (Doorbar). The Division has close links with virologists in the Department of Medicine, the Cambridge Veterinary School, the Wellcome Trust Sanger Institute and the MRC Laboratory of Molecular Biology.

Teaching

Aspects of Virology are taught in the 2nd year (Part IB) and the 3rd year (Part II) courses in Pathology and in the Postgraduate Education Programme.

Lab Managers: Nadine Law (Addenbrooke's Biomedical Campus) and Anna Rudd (Tennis Court Road)

Contact: sec.vir@path.cam.ac.uk

Note: The Division of Virology comprises virologists based in the Laboratories’ Block at the Addenbrooke’s Biomedical Campus and within the Department of Pathology’s laboratories in Tennis Court Road in central Cambridge.