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Firth Research 1

Fig 1. Above - map of the poliovirus genome showing the polyprotein-encoding sequence (blue), UTRs (black), and known functional RNA elements (Goodfellow et al 2000, PMID 10775595; Liu et al 2009, PMID 19781674; Song et al 2012, PMID 22886087; Burrill et al 2013, PMID 23966409). Below - conservation at synonymous sites in an alignment of 50 enterovirus sequences: synonymous substitution rate relative to the genome average (brown) and statistical significance (red). All known functional RNA elements embedded within the polyprotein-encoding sequence are easily detected, besides a few additional elements in the region encoding 3D.
Firth Research 1
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