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Dysregulated microRNA (miRNA) expression in malignant germ cell tumours. miRNAs from the miR-371∼373 and miR-302/367 clusters (red boxes) are over-expressed in malignant GCTs. Downregulated microRNAs include those from the let-7 family as well as miR-99a, miR-100, and miR-125b (blue boxes). Mechanisms that potentially underly these changes are shown in grey boxes. miRNA dysregulation may be exploited clinically through serum miRNA testing for over-expressed miRNAs (green oval) or therapeutic targeting of overexpressed miRNAs and/or replenishment of under-expressed miRNAs (orange ovals).
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