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koronakis-20180724

Left, the Lol lipoprotein trafficking system in Gram-negative bacteria. Lipoproteins (LP) are extracted from the inner membrane (IM) by LolCDE, transported across the periplasm by the chaperone LolA and then passed to the receptor LolB which catalyses insertion into the outer membrane (OM). Right, close-up view showing the structural features of LolC, the Hook and Pad, that recruit the LolA chaperone. Below, movie showing the structural model of the full-length LolCDE transporter bound to LolA and their predicted movements based on the mechanotransmission mechanism of the related MacB transporter.
koronakis-20180724
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