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Influenza virus replication and host adaptation

Supervisor: Dr. A.J.W. te Velthuis
Based at the Division of Virology, Addenbrooke’s Hospital

te-velthuis1RNA viruses pose a significant threat to our wellbeing and economy. One of the most threatening is the influenza A virus, which infects an estimated 13 million and kills about half a million people every winter. Moreover, emerging pandemic and avian influenza viruses, such as the 1918 Spanish Flu, are even more disastrous. It is therefore crucial that we understand how the influenza virus amplifies itself and why certain variants are more lethal. This project will use biochemical and real-time single-molecule techniques to study and better understand the enzyme that drives the replication of the influenza genome.te-velthuis2

Recent publications

Nilsson, te Velthuis and Fodor; Role of the PB2 627 domain in influenza A virus polymerase function. J Virol 2017.

Te Velthuis and Fodor; Influenza virus RNA polymerase: insights into the mechanisms of viral RNA synthesis. Nature Rev Microbiol 2016.

Robb, te Velthuis et al; Single-molecule FRET reveal the pre-initiation and initiation conformations of influenza virus promoter RNA. Nucleic Acids Res 2016.

Te Velthuis et al; The role of the priming loop in influenza A virus RNA synthesis. Nature Microbiology 2016.

Te Velthuis; Common and unique features of RNA virus RNA polymerase. Cell Mol Life Sci 2014.