Archived Publications 1995-2002

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2002

Hoffmann, K.F., Wynn, T.A. and Dunne, DW. Cytokine-mediated host responses during schistosome infections; walking the fine line between immunological control and immuno-pathology. Adv Parasitol 52, 266-307, 2002. PubMed

Dunne, D.W. and Vennervald, B.J. Schistosomiasis. In: Oxford Textbook of Medicine, Eds Warrell DA, Cox TM & Firth JD, 4th Edition, Vol.1, pp.830-837, 2003.

Utzinger, J., Vounarsou, P., Goran, E.K., Tanner, M. and Booth, M.B. Reduction in the prevalence and intensity of hookworm infections after praziquantel treatment for schistosomiasis infection. Int. J. Parasitol. 32, 759-765, 2002. PubMed

Hoffman, K.F., Johnston, D.A. and Dunne, D.W. Identification of Schistosoma mansoni gender-associated gene transcripts by cDNA microarray profiling. Genome Biology 3, (8), 2002. PubMed

Dutra, W.O., Correa-Oliveira, R., Dunne, D.W., Cecchini, L.F., Fraga, L., Roberts, M., Soares-Silveira, A.M., Webster, M., Yssel, H. and Gollob, K.J. Polarized Th2 like cells, in the absence of Th0 cells, are responsible for lymphocyte produced IL-4 in high IgE-producer schistosomiasis patients. MBC Immunol., 3, (8), 2002. PubMed

2001

Utzinger, J., Booth, M., N'Goran, E.K., Moller, I., Tanner, M. and Lengeler, C. Relative contribution of day-to-day and intra-specimen variation in faecal egg counts of Schistosoma mansoni before and after treatment with praziquantel. Parasitology 122, 537-544, 2001. PubMed

Smith,P., Dunne, D.W. and Fallon, P.G. Defective in vivo induction of functional type 2 cytokine responses in aged mice. Eur. J. Immunol. 31, 1495-1502, 2001. PubMed

Fallon, P.G., Allen, R.L. and Rich, T. Primitive toll signalling: bugs, flies, worms and man. Trends Immunol. 22, 63-66, 2001.

Fallon, P.G., Emson, C.L., Smith, P. and McKenzie, A.M. IL-13 overexprression predisposes to anaphylaxis following antigen sensitization. J. Immunol. 166, 2712-2716, 2001. PubMed

Dunne, D.W. and Mountford, A. Resistance to infection in humans and animal models. In: Schistosomiasis, Ed. Mahmoud, A.A.F., Imperial College Press 2001

1995 - 2000

Townsend, M.J., Fallon, P.G., Matthews, D.J., Jolin, H.E. and McKenzie, A.N.J. T1/ST2-deficient mice demonstrate the importance of T1/ST2 in developing primary Th2 responses. J. Exp. Med. 191 , 1069-1076, 2000.

Remoue, F., Rogerie, F., Gallissot, M.C., Guyatt, H.L., Neyrinck, J.L., Diakkhate, M.M., Niang, M., Butterworth, A.E., Auriault, C., Capron, A. and Riveau, G. Sex-dependent neutralizing humoral response to Schistosoma mansoni 28GST antigen in infected human populations. J. Inf. Dis. 181, 1855-1859, 2000.

Fallon, P.G., Smith, P., Richardson, E.J., Jones, F.J., Faulkner, H.C., Van Snick, J., Renauld, J-C., Grencis, R.K. and Dunne, D.W. (2000) Expression of interleukin-9 leads to Th2 cytokine-dominated responses and fatal enteropathy in mice with chronic Schistosoma mansoni infections. Infect. Immun. 68, 6005-6011, 2000.

King, A., Allan, D.S.J., Bowen, J.M., Powis, S.J., Joseph, S., Verma, S., Hiby, S.E., McMichael, A., Loke, Y.W. and Braud, V. HLA-E is expressed on trophoblast and interacts with CD94/NKG2 receptors on decidual NK cells. Eur. J. Immunol. 30, 1623-1631, 2000.

Rosa-Brunet, L., Joseph, S., Dunne, D.W. and Fried, B. Immune responses during the acute stages of infection with the intestinal trematode Echinostoma caproni. Parasitology 120, 565-571, 2000.

King, A., Hiby, S.E., Gardner, L., Joseph, S., Bowen, J.M., Verma, S., Burrows, T.D. and Loke, Y.W. Recognition of trophoblast HLA class I molecules by decidual NK cell receptors a review. Placenta 21 , S81-S85, 2000.

King, A., Burrows, T.D., Hiby, S.E., Bowen, J.M., Joseph, S., Verma, S., Lim, P.B., Gardner, L., Le Bouteiller, P., Ziegler, A., Uchanska-Ziegler, B. and Loke, Y.W. Surface expression of HLA-C antigen by human extravillous trophoblast. Placenta 21, 376-387, 2000.

Fallon, P.G., Richardson, E.J., McKenzie, G.J. and McKenzie, A.N.J. Schistosome infection of transgenic mice defines distinct and contrasting pathogenic roles for IL-4 and IL-13: IL-13 is a profibrotic agent. J. Immunol. 164, 2585-2591, 2000.

Fallon, P.G. Immunopathology of schistosomiasis: a cautionary tale of mice and men. Immunol. Today 21, 29-34, 2000.

Fallon, P.G., Richardson, E., Smith, P. and Dunne, D.W. Elevated type 1, diminished type 2 cytokines and impaired antibody responses are associated with hepatotoxicity and mortalities during Schistosoma mansoni infection of CD4-depleted mice. Eur. J. Immunol. 30 , 470-480, 2000.

Hernandez-Hoyos, G., Joseph, S., Miller, N.G.A. and Butcher, G.W. The lymphopenia mutation of the BB rat causes inappropriate apoptosis of mature thymocytes. Eur. J. Immunol. 29 , 1832-1841, 1999.

Hernandez, M.G.H., Hafalla, J.C., Acosta, L.P., Aligui, F.F., Aligui, G.D., Ramirez, B., Dunne, D.W. and Santiago, M.L. Paramyosin is a major target of the human IgA response against Schistosoma japonicum . Parasite Immunol. 21, 641-647, 1999.

Marguerite, M., Gallissot, M.C., Diagne, M., Moreau, C., Diakkhate, M.M., Roberts, M., Remoue, F., Thiam, A., Decam, C., Rogerie, F., Cottrez, F., Neyrinck, J.L., Butterworth, A.E., Sturrock, R.F., Piau, J.P., Daff, B., Niang, M., Wolowczuk, I., Riveau, G., Auriault, C. and Capron, A. Cellular immune responses of a Senegalese community recently exposed to Schistosoma mansoni: correlations of infection level with age and inflammatory cytokine production by soluble egg antigen-specific cells. Trop. Med. Int. Health 4, 530-543, 1999.

Rosa Brunet, L., Beall, M., Dunne, D.W. and Pearce, E.J. Nitric oxide and the Th2 response combine to prevent severe hepatic damage during Schistosoma mansoni infection. J. Immunol. 163 , 4976-4984, 1999.

Rosa Brunet, L., Knopf, M.A. and Pearce, E.J. Schistosoma mansoni: IL4 is necessary for concomitant immunity. J. Parasitol. 85, 734-736, 1999.

Marshall, A.J., Rosa Brunet, L., van Gessel, Y., Alcaraz, A., Bliss, S.K., Pearce, E.J. and Denkers, E.Y. Toxoplasma gondii and Schistosoma mansoni synergize to promote hepatocyte dysfunction associated with high levels of plasma TNF- a and early death in C57BL/6 mice. J. Immunol. 163 , 2089-2097, 1999.

Rosa Brunet, L., Sabin, E.A., Cheever, A.W., Kopf, M.A. and Pearce, E.J. IL-5 plays a role in the development of IL-4 producing non-T non-B cells during murine schistosomiasis mansoni but is not required for the expression of a Th2 response or host resistance mechanisms. Infect. Immun. 67, 3014-3018, 1999.

Santiago, M.L., Hafallal, J.C.R., Kurtis, J.D., Wiest, P.M., Olds, G.R., Dunne, D.W. and Ramirez, B.L. Identification of the Schistosoma japonicum 22.6-kDa antigen as a major target of the protective human IgE response: similarity of IgE-binding epitopes to allergen peptides. Int. Arch. Allergy Immunol. 117, 94-104, 1999.

Dunne, D.W. and Pearce, E.J. Immunology of hepatosplenic schistosomiasis mansoni: a human pespective. Immunoregulation of Schistosomiasis. Microbes Infect 1, 553-560, 1999.

Naus, C., Kimani, G., Ouma, J.H., Fulford, A.J.C., Webster, M., van Dam. G.J., Deelder, A.M., Butterworth, A.E. and Dunne, D.W. Development of antibody isotype responses to Schistosoma mansoni in an immunologically naive immigrant population: influence of infection duration, infection intensity, and host age. Infect. Immun. 67 , 3444-3451, 1999.

McKenzie, G.J., Fallon, P.G., Emson, C.L., Grencis, R.K. and McKenzie, A.N.J. Simultaneous disruption of interleukin (IL)-4 and IL-13 defines individual roles in T helper cell type 2-mediated responses. J. Exp. Med. 189, 1565-1572, 1999.

Fallon, P.G. and Dunne, D.W. Tolerisation of mice to Schistosoma mansoni egg antigens causes elevated type 1 and diminished type 2 cytokine responses and increased mortality in acute infection. J. Immunol. 162, 4122-4132, 1999.

Nutten, S., Papin, J-P., Dunne, D.W., MacGregor, J., Trottein, F. and Capron, M. Selectin-Lewisx are required as co-receptors in antibody-dependent cell-mediated cytotoxicity of human eosinophils to Schistosoma mansoni schistosomula. Eur. J. Immunol. 29, 799-808, 1999.

Cooke, A., Tonks, P., Jones, F.M., O'Shea, H., Hutchings, P., Fulford, A.J.C. and Dunne, D.W. (1998) Infection with Schistosoma mansoni prevents insulin dependent diabetes mellitus in NOD mice. Parasite Immunol. 21, 169-176, 1999.

Hafalla, J.C., Alamares, J.G., Acosta, L.P., Dunne, D.W., Ramirez, B.L. and Santiago, M.L. Molecular identification of a Schistosoma japonicum 21.7 kDa antigen as a target of the human IgE response. Mol. Biochem. Parasitol. 98, 157-161, 1999.

Pearce, E.J., La Flamme, A., Sahn, E. and Rosa Brunet, L. The initiation and function of the responses during infection with Schistosoma mansoni. Adv. Exp. Med. Biol. 452 , 67-73, 1999.

Hamilton, J.V., Chiodini, P.L. Fallon, P.G. and Doenhoff, M.J. Periodate-sensitive immunological cross-reactivity between keyhole limpet haemocyanin (KLH) and serodiagnostic Schistosoma mansoni egg antigens. Parasitology 118, 83-89, 1999.

Dunne, D.W. Human schistosomiasis - immunology in a foreign field. Immunology News 5, 168-170, 1999.

Kabatereine, N.B., Vennervald, B.J., Ouma, J.H., Kemijumbi, J., Butterworth, A.E., Dunne, D.W. and Fulford, A.J.C. Adult resistance to schistosomiasis: age-dependence of reinfection remains constant in communities with diverse exposure patterns. Parasitology 118 , 101-105, 1999.

Butterworth, A.E. Immunological aspects of human schistosomiasis. Brit. Med. Bull. 54, 357-368, 1998.

Ouma, J.H., Fulford, A.J.C., Kariuki, C., Gachuhi, K., Muchemi, G., Butterworth, A.E. and Dunne, D.W. The development of schistosomiasis mansoni in an immunologically naive immigrant population in Masongaleni, Kenya. Parasitology 117, 123-132, 1998.

McKenzie, G.J., Emson, C.L., Bell, S.E., S. Anderson, Fallon, P.G., Zurawski, G., Murray, R., Grencis, R. and McKenzie, A.N.J. Impaired development of Th2 cells in IL-13-deficient mice. Immunity 9 , 423-432, 1998.

Hagan, P., D'Ndhlovu, P. and Dunne, D.W. Schistosome immunology: more questions than answers. Parasitol. Today 14, 407-412, 1998.

Baz, A., Hernan, C., Marta, M., Lucia, C., Nieto, A., Dunne, D.W. and Jones, F.M. Fc-binding molecules specific for human IgG1 and IgG3 are present in Echinococcus granulosus protoscoleces. Parasite Immunol. 20, 399-404, 1998.

Brunet, L.R., Dunne, D.W. and Pearce, E.J. Cytokine interaction and immune responses during Schistosoma mansoni infection. Parasitol. Today 14, 422-427, 1998.

Fallon, P.G. Schistosome Resistance to Praziquantel. Drug Resistance Updates 1, 236-241, 1998.

Pereira, C., Fallon, P.G., Cornette, J., Capron, A., Doenhoff, M.J. and Pierce, R.J. Alterations in cytochrome oxidase expression between praziquantel-resistant and susceptible strains of Schistosoma mansoni . Parasitology 117, 63-73, 1998.

Webster, M., Roberts, M., Fulford, A.J.C., Marguerite, M., Gallisot, M-C., Diagne, M., Niang, M., Riveau, G., Capron, A. and Dunne, D.W. Human isotype responses to rSm22.6 are associated with infection intensity rather than age per se, in a recently established foci of schistosomiasis mansoni. Trop. Med. Int. Health 3, 318-326, 1998.

Fallon, P.G., Smith, P. and Dunne, D.W. Type 1 and Type 2 cytokine producing murine CD4+ and CD8+ T cells in acute Schistosoma mansoni infection. Eur. J. Immunol. 28, 1408-1416, 1998.

Fulford, A.J.C., Webster, M., Ouma, J.H., Gachuhi, K. and Dunne, D.W. Puberty, immunity and age-related changes in susceptibility to schistosome infection. Parasitol. Today 14,23-26, 1998

Fallon, P.G., Richardson, E.J., Jones, F.M. and Dunne, D.W. Dehydroepidandrosterone sulfate treatment of mice modulates infection with Schistosoma mansoni. Clin. Diag. Lab. Immunol. 5 , 251-251, 1998.

Mwatha, J.K., Kimani, G., Kamau, T., Mumo, J., Ouma, J.H., Fulford, A.J.C., Jones, F.M., Butterworth, A.E. and Dunne, D.W. High levels of TNF, sTNF receptors, sICAM-1 and IFN- g , but low levels of IL-5, are associated with hepatosplenic disease in human schistosomiasis mansoni. J. Immunol. 160, 1992-1999, 1998.

Sturrock, R.F., Ouma, J.H., Kariuki, H.C., Thiong'o, F.W., Koech, D.K. and Butterworth, A.E. Quality control of Kato slide counts for Schistosoma mansoni: a review of 12 years' experience in Kenya. Bull. World Health Org. 75, 469-475, 1997.

Webster, M., Correa-Oliveira, R., Gazzinelli, G., Viana, I.R.C., Alves de Oliveira Fraga, L., Soares Silveira, A.M. and Dunne, D.W. Factors affecting high and low human IgE responses to schistosome worm antigens in an area of Brazil endemic for Schistosoma mansoni and hookworm. Am. J. Trop. Med. Hyg. 57, 487-494, 1997.

Monteyne, P., Renauld, J.C., Van Broeck, J., Dunne, D.W., Brombacher, F., and Coutelier, J.P. IL-4-independent regulation of in vivo IL-9 expression. J. Immunol. 159, 2616-2623, 1997.

Webster, M., Fallon, P.G., Fulford, A.J.C., Butterworth, A.E., Ouma, J.H., Kimani, G. and Dunne, D.W. Effect of praziquantel and oxaminiquine treatment on human isotype responses to Schistosoma mansoni : elevated IgE to adult worm. Parasite Immunol. 19 , 333-335, 1997.

O'Reilly, L.A., Gu, D., Sarvetnick, N., Edlund, H., Phillips, J.M., Fulford, A.J.C. and Cooke, A. Alpha cell neogenesis in an animal model of IDDM. Diabetes 46, 599-606, 1997

Fallon, P.G., Murbarak, J.S., Fookes, R.E., Niang, M., Butterworth, A.E., Sturrock, R.F. and Doenhoff, M.J. Schistosoma mansoni : maturation state and drug susceptibility of different geographic isolates. Exp. Parasitol. 86, 29-36, 1997.

Kloos, H., Fulford, A.J.C., Butterworth, A.E., Sturrock, R.F., Ouma, J.H., Kariuki, H.C., Thiong'o, F.W., Dalton, P.R. and Klumpp, R.K. Spatial patterns of human water contact and Schistosoma mansoni transmission and infection in four rural reas in Machakos District, Kenya. Soc. Sci. Med. 44, 949-968, 1997.

Webster, M., Libranda-Ramirez, B.D.L., Aligui, G.D., Olveda, R.M., Ouma, J.H., Kariuki, H.C., Kimani, G., Olds, G.R., Fulford, A.J.C., Butterworth, A.E. and Dunne, D.W. The influence of sex and age on antibody isotype responses to Schistosoma mansoni and Schistosoma japonicum in human populations in Kenya and the Philippines. Parasitology 114 , 383-393, 1997.

Webster, M., Fallon, P.G., Fulford, A.J.C., Butterworth, A.E., Ouma, J.H., Kimani, G. and Dunne, D.W. IgG4 and IgE responses to Schistosoma mansoni adult worm after treatment. J. Infect. Dis. 175 , 493-494, 1997.

Dunne, D.W., Webster, M., Smith, P., Langley, J.G., Richardson, B.A., Fulford, A.J.C., Butterworth, A.E., Sturrock, R.F., Kariuki, H.C. and Ouma, J.H. The isolation of a 22kDa band after SDS-PAGE of Schistosoma mansoni adult worms and its use to demonstrate that IgE responses against the antigen(s) it contains are associated with human resistance to reinfection. Parasite Immunol. 19, 79-89, 1997.

Sturrock, R.F., Kariuki, H.C., Thiong'o, F.W., Gachare, J.W., Omondi, B.G.O., Ouma, J.H., Mbugua, G. and Butterworth, A.E. Schistosomiasis mansoni in Kenya: relationship between infection and anaemia in school children at the community level. Trans. Roy. Soc. Trop. Med. Hyg. 90 , 48-54, 1996.

Agnew, A., Fulford, A.J.C., Mwange, M.T., Kimani, G., Gutsmann, V., Krijger, F.W., Sturrock, R.F., Vennervald, B.J., Ouma, J.H., Butterworth, A.E. and Deelder, A.M. Age dependent reduction of schistosome fecundity in Schistosoma haematobium but not Schistosoma mansoni infections in man. Am. J. Trop. Med. Hyg. 55, 338-343, 1996.

Butterworth, A.E., Dunne, D.W., Fulford, A.J.C., Ouma, J.H. and Sturrock, R.F. Immunity and morbidity in Schistosoma mansoni infection: quantitative aspects. Am. J. Trop. Med. Hyg. 55, 109-115, 1996.

Fallon, P.G. and Hagan, P. Blood and guts at Bangor. Parasitology Today 12, 460-462, 1996.

Webster, M., Fulford, A.J.C., Braun, G., Ouma, J.H., Kariuki, H.C., Havercroft, J.C., Gachuhi, K., Sturrock, R.F., Butterworth, A.E., and Dunne, D.W. Human IgE responses to a recombinant 22.6kDa antigen from Schistosoma mansoni adult worms are associated with low intensities of reinfection after treatment. Infect. Immun. 64, 4042-4046, 1996.

Fulford, A.J.C., Ouma, J.H., Kariuki, H.C., Thiong'o, F.W., Kloos, H., Klumpp, R.K., Sturrock, R.F. and Butterworth, A.E. Water contact observations in Kenyan communities endemic for schistosomiasis: methodology and patterns of behaviour. Parasitology 113, 223-241, 1996.

Salinas, G., Sinha, K., Cooper, J.P., Whitworth, J.A.G. and Taylor, D.W. Human isotype antibody responses to Onchocerca volvulus glutathione S-transferase. Parasite Immunol. 18 , 377-386, 1996.

Fallon, P.G., Warren, J. and Behnke, J.M. Evaluation of immune dependence of anthelmintic treatment of Heligmosomoides polygyrus in CBA/Ca mice. Int. J. Parasitol. 26, 557-560, 1996.

Fallon, P.G., Tao, L-F., Ismail, M.M. and Bennett, J.L. Schistosome resistance to praziquantel: fact or artefact? Parasitol. Today 12, 316-320, 1996.

Fulford, A.J.C., Butterworth, A.E., Dunne, D.W., Sturrock, R.F. and Ouma, J.H. Some mathematical and statistical issues in assessing the evidence for acquired immunity to schistosomiasis. In: Models for Infectious Diseases, March 1993, Eds Isham V & Medley, G., Publication of the Newton Institute 6, Cambridge University Press, pp.139-259, 1996.

Chunge, R.N., Karumba, P.N., Ouma, J.H., Thiong'o, F.W., Sturrock, R.F. and Butterworth, A.E. Polyparatism in two rural communities with endemic Schistosoma mansoni infection in Machakos District, Kenya. J. Trop. Med. Hyg. 98, 440-444, 1995.

Butterworth, A.E. and Thomas, J.E.P. Schistosomiasis. In: Oxford Textbook of Medicine, Third Edition, Eds. Weatherall, D., Ledingham, J.G.G., Warrell, D.A. Oxford University Press, 1995.

Chan, M.S., Guyatt, H.L., Bundy, D.A.P., Booth, M., Fulford, A.J.C. and Medley, G.F. The development of an age structured model for schistosomiasis transmission dynamics and control and its validation for Schistosoma mansoni . Epidemiol. Infect. 115, 325-344, 1995.

Agnew, A., Fulford, A.J.C., De Jonge, N., Krijger, F.W., Rodriguez-Chacon, M., Gutsmann, V. and Deelder, A.M. The relationship between worm burden and levels of a circulating antigen (CAA) in mice infected with five species of Schistosoma. Parasitology 111 , 67-76, 1995.

Dunne, D.W., Hagan, P and Abath, F.G.C. Prospects for immunological control of schistosomiasis. The Lancet 345 , 1488-1492, 1995.

Curry, A.J., Else, K.J., Jones, F., Bancroft, A., Grencis, R.K. and Dunne, D.W. Evidence that cytokine-mediated immune interactions induced by Schistosoma mansoni alter disease outcome in mice concurrently infected with Trichuris muris. J. Exp. Med. 181, 769-774, 1995.

Fulford, A.J.C., Butterworth, A.E., Ouma, J.H. and Sturrock, R.F. A statistical approach to schistosome population dynamics and estimation of the lifespan of Schistosoma mansoni in man. Parasitology 110 , 307-316, 1995.

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