Other Cancer Cell Lines Chromosome 8

Other Cancer Cell Lines: Rearrangements of Chromosome 18 These cell lines were originally reported as breast (MDA-MB-435 and MT-1) and pancreatic (SW979) but are likely to be respectively a melanoma, HeLa and cervical cancer lines (Ellison et al, 2002; Macleod et al, 1999; Moore et al, 2001).

Ideograms summarising FISH results, for each cell line, of a selection of arm paints, band paints and PACs mapping to chromosome 8. • All copies of chromosome 8 are shown, including apparently normal ones. • Not all BACS were used for every cell line, so only those used, and which gave a signal, are shown. • The identity of the translocation partner is indicated for each derivative. • '?' indicates that the translocation partner is unknown. • The G-band pattern for chromosome 8 is based on UCSC Genome Browser positions. • The position of the BACs is to scale. • Filled black triangles indicate approximate positions of 8p breakpoints. • Filled grey triangles indicate approximate positions of 8q breakpoints. • Unfilled triangles indicate breakpoints that are not counted as they either appear balanced, or the (derivative) chromosome had been duplicated.


Ellison G, Klinowska T, Westwood RF, Docter E, French T, Fox JC (2002) Further evidence to support the melanocytic origin of MDA-MB-435. Molecular Pathology 55:294-9 MacLeod RA, Dirks WG, Matsuo Y, Kaufmann M, Milch H, Drexler HG (1999) Widespread intraspecies cross-contamination of human tumor cell lines arising at source. Int J Cancer 83(4):555-63 Moore PS, Sipos B, Orlandini S, Sorio C, Real FX, Lemoine NR, Gress T, Bassi C, Klöppel G, Kalthoff H, Ungefroren H, Löhr M, Scarpa A (2001) Genetic profile of 22 pancreatic carcinoma cell lines. Analysis of K-ras, p53, p16 and DPC4/Smad4. Virchows Archives 439(6):798-802

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