Molecular Cytogenetics of Common Epithelial Cancers > Breast Carcinoma cell lines
The following breast cancer and normal breast cell lines have been analysed by SKY. A few have also been analyzed by CGH. The linked pages show representative SKY karyotypes and some additional comment.
|BT549||KPL-1 ||SK-BR-7 |
|CAL51 ||MaTu/Ham (HeLa) [1,2]||SUM-52|
|GI-101||MDA-MB-134 ||SUM-159 [1, 6]|
|HCC38||MDA-MB-157 ||T-47D |
|HCC70||MDA-MB-175 ||VP229 |
|HCC1143||MDA-MB-361 ||VP267 |
|HCC1419||MDA-MB-435 [1, 7]||ZR-75-30 |
|HCC1599||MT-1 (HeLa) [1,2]||HB4a [1, 3]|
|HCC1806||MT-3 [1, 8]|
|HCC1937 [4, 5]||PMC42 ||Selected CGH |
References to the SKY data and comments.
Unreferenced lines are unpublished work by Susanna Cooke, Katherine Blood, Mira Grigorova and Joanne Staines (née Davidson)
 Davidson et al (2000) Br J Cancer 83, 1309-17.
 These lines are HeLa contaminants, see MacLeod et al (1999) Int J Cancer 83, 555-563.
 Immortalized normal lumenal breast epithelium; Stamps AC,
 Grigorova M, Staines JM, Ozdag H, Caldas C, Edwards PA. Possible causes of chromosome instability: comparison of chromosomal abnormalities in cancer cell lines with mutations in BRCA1, BRCA2, CHK2 and BUB1. Cytogenet Genome Res. 2004;104(1-4):333-40. PMID: 15162061
 BRCA1 mutant
 The SUM lines are described at http://www.cancer.med.umich.edu/breast_cell/Production/. CGH of these is included in Forozan, F., Mahlamaki, E. H., Monni, O., Chen, Y., Veldman, R., Jiang, Y. Gooden, G. C., Ethier, S. P., Kallioniemi, A., Kallioniemi, O-P. "Comparative Genomic Hybridization Analysis of 38 Breast Cancer Cell Lines: A Basis for Interpreting Complementary DNA Microarray Data". Cancer Research, 60:4519-4525, 2000.
 Now known to be from a melanoma, see linked page
 KPL-1 and MT-3 have been shown by SNP analysis to be identical to MCF7 and colorectal line LS174T respectively (http://www.sanger.ac.uk/genetics/CGP/Genotyping/synlinestable.shtml)
Breast Cell Lines
revised 28 June 2004