Molecular Cytogenetics of Common Epithelial Cancers > Breast Carcinoma cell lines

Breast Carcinoma Cell Lines

The following breast cancer and normal breast cell lines have been analysed by SKY. A few have also been analyzed by CGH. The linked pages show representative SKY karyotypes and some additional comment.

BT20 HCC1954 SK-BR-3 [1]
BT549 KPL-1 [8] SK-BR-7 [1]
CAL51 [1] MaTu/Ham (HeLa) [1,2] SUM-52
DU4475 MCF7 [1]
GI-101 MDA-MB-134 [1] SUM-159 [1, 6]
HCC38 MDA-MB-157 [1] T-47D [1]
HCC70 MDA-MB-175 [1] VP229 [1]
HCC1143 MDA-MB-361 [1] VP267 [1]
HCC1187 MDA-MB-415 ZR-75-1 [1]
HCC1419 MDA-MB-435 [1, 7] ZR-75-30 [1]
HCC1500 MDA-MB-453
HCC1569 MDA-MB-468 Normal Breast:
HCC1599 MT-1 (HeLa) [1,2] HB4a [1, 3]
HCC1806 MT-3 [1, 8]
HCC1937 [4, 5] PMC42 [1] Selected CGH [1]

References to the SKY data and comments.

Unreferenced lines are unpublished work by Susanna Cooke, Katherine Blood, Mira Grigorova and Joanne Staines (née Davidson)

[1] Davidson et al (2000) Br J Cancer 83, 1309-17.

[2] These lines are HeLa contaminants, see MacLeod et al (1999) Int J Cancer 83, 555-563.

[3] Immortalized normal lumenal breast epithelium; Stamps AC, Davies SC , Burman J, O'Hare MJ. Analysis of proviral integration in human mammary epithelial cell lines immortalized by retroviral infection with a temperature-sensitive SV40 T-antigen construct. Int J Cancer. 1994 Jun 15;57(6):865-74.

[4] Grigorova M, Staines JM, Ozdag H, Caldas C, Edwards PA. Possible causes of chromosome instability: comparison of chromosomal abnormalities in cancer cell lines with mutations in BRCA1, BRCA2, CHK2 and BUB1. Cytogenet Genome Res. 2004;104(1-4):333-40. PMID: 15162061

[5] BRCA1 mutant

[6] The SUM lines are described at http://www.cancer.med.umich.edu/breast_cell/Production/. CGH of these is included in Forozan, F., Mahlamaki, E. H., Monni, O., Chen, Y., Veldman, R., Jiang, Y. Gooden, G. C., Ethier, S. P., Kallioniemi, A., Kallioniemi, O-P. "Comparative Genomic Hybridization Analysis of 38 Breast Cancer Cell Lines: A Basis for Interpreting Complementary DNA Microarray Data". Cancer Research, 60:4519-4525, 2000.

[7] Now known to be from a melanoma, see linked page

[8] KPL-1 and MT-3 have been shown by SNP analysis to be identical to MCF7 and colorectal line LS174T respectively (http://www.sanger.ac.uk/genetics/CGP/Genotyping/synlinestable.shtml)

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revised 28 June 2004