Molecular Cytogenetics of Common Epithelial Cancers > Colon Carcinoma cell lines
The following colon cancer cell lines have been analysed by SKY [1, 2], with in most cases verification of the SKY by 2- and 3-colour conventional FISH. The linked pages show representative SKY karyotypes and some additional comment.
|Microsatellite-stable lines||ref||Microsatellite-unstable lines||ref||Microsatellite status unknown||ref|
CGH of the 17 lines reported in  in a composite figure: high-resolution gif image (300kb) 
References and comments
 Abdel-Rahman WM, Katsura K, Rens W, Gorman PA, Sheer D, Bicknell D, Bodmer WF, Arends MJ, Wyllie AH, Edwards PA Spectral karyotyping suggests additional subsets of colorectal cancers characterized by pattern of chromosome rearrangement. Proc Natl Acad Sci U S A. 2001 98(5):2538-43. PMID: 11226274
 Grigorova M, Staines JM, Ozdag H, Caldas C, Edwards PA. Possible causes of chromosome instability: comparison of chromosomal abnormalities in cancer cell lines with mutations in BRCA1, BRCA2, CHK2 and BUB1. Cytogenet Genome Res. 2004;104(1-4):333-40. PMID: 15162061
 VACO400 and 429 have mutations in Bub1; DLD-1 and HCT-15 are from the same tumour and have biallelic inactivation of CHK2.
 Chen TR, Dorotinsky CS, McGuire LJ, Macy ML, Hay RJ: DLD-1 and HCT-15 cell lines derived separately from colorectal carcinomas have totally different chromosome changes but the same genetic origin. Cancer Genet Cytogenet 81:103-108 (1995).
 Ghadimi BM, Sackett, DL, Difilippantonio MJ, Schrock E, Neumann T, Jauho A,Auer G, ried T: Centrosome amplification and instability occurs exclusively in aneuploid, but not in diploid colorectal cancer cell lines, and correlates with numerical chromosomal aberrations. Genes Chrom Cancer 27: 183-190 (2000).
revised 28 June 2004