HCT-15

Colon Cancer Cell Line

Microsatellite-unstable line, from the same tumour as DLD-1. Shares various mutations with DLD-1, including biallelic CHK2 mutation, but has different karyotype (Chen et al., 1995).

Diploid with three structural abnormalities—an inversion, a deletion and an unbalanced translocation —as previously determined by banding (Chen et al., 1995). Karyotype typical of ‘chromosomally-stable’ cell lines.

Abnormal chromosomes only

only abnormal chromosomes and their normal pair are shown. a, normal 8 and translocated 8, der(8)t(8;17); b, normal and inverted 11; c, normal and deleted 17.

HCT-15: 46 (45–47) XY, der(8)t(8;17), inv(11), der(17)del(17)

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FISH, SKY and CGH

Colon Cancer Cell Lines