Molecular Cytogenetics of Common Epithelial Cancers > Breast Carcinoma cell lines > ZR-75-1
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Breast Carcinoma Cell Line |
Molecular Cytogenetics of Common Epithelial Cancers > Breast Carcinoma cell lines > ZR-75-1
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Breast Carcinoma Cell Line |
| Description | A highly rearranged, near triploid cell line, held at the ATCC cell line, obtained from the ECACC. |
| Notable Features | Translocations involve chromosomes 1, 6, 7, 8, 10, 11, 12, 13, 14, 15, 16, 17 and 22. One marker is duplicate and another triplicate. Deletions were detected on chromsomes 1, 6 and 19, and isochromsomes formed from 16 (p and q) and 20. An HSR is present on chromosome 1. |
| Representative SKY Karyotype |  |
| 72(51-75).1x2, der(1)t(1;12)(?;q14), del(1)(p?)hsr(1)?, 2x3, 3x3, 4x3, 5x3, 6x1, del(6)(q?)x2, 7x3, der(22)t(7;22)x3, 8x3, der(8)t(8;11)(p12;?), 9x3, 10x3, der(11)t(11;17)x2, 12x3, der(?)t(12;16), der(?)t(1;12), 13x2, 14x2, der(14)t(13;14), 15x2, der(15)t(10;15), der(15)t(1;15), 16x1, i(16)(q), i(16)(p), 17x2, der(?)t(6;17), 18x3, 19x2, del(19)(p?), 20x2, i(20)(q), 21x2, 22x2, der(22)t(15;22)*, Xx3 cp[10] | |
| CGH results | |
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