Molecular Cytogenetics of Common Epithelial Cancers > 'Breast Carcinoma' cell lines > MDA-MB-435

Breast Carcinoma Cell Line

Description Warning: this line has been shown to be from a melanoma, see Ellison et al (2002) J Clin Pathol: Mol Pathol 55, 294-9 and refs therein.

A highly rearranged, near triploid cell line held at the ATCC, obtained from Dr Mike O'Hare.

   
Notable Features Translocations involve 1, 3, 6, 7, 8, 10, 11, 13, 14, 15, 16, 18, 20, 21 and 22. One marker has been duplicated. Deletions were detected on chromosomes 2, 3, 5, 8, 10 and 20.
   
Representative SKY Karyotype
   
   
57(44-62).1x1, der(1)t(1;7), der(1)t(1;10), 2x2, del(2)(p?), 3x2, del(3)(p?), der(3)t(3;19), 4x2, 5x2, del(5)(q?), 6x2, der(6)t(6;7), 7x2, 8x1, del(8)(p), der(8)t(8;15), 9x2, 10x2, del(10), der(10)t(10;18), 11x2, der(11)t(8;11), 12x2, 13x1, der(13)t(11;13), 14x1, der(14)t(1;14), der(?)t(14;16), 15x2, 16x2, 17x2, 18x1, der(?)t(18;19), 19x1, der(?)t(6;19), 20x1, del(20), der(?)t(20;21)x2, 21x1, 22x2, der(22?)t(6;22), Xx2 cp[10]
   
CGH results  
   

   
   


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