Molecular Cytogenetics of Common Epithelial Cancers > Breast Carcinoma cell lines > HCC1143

HCC1143

Breast Cancer Cell Line

Description

A near-tetraploid cell line from mammary gland; breast; duct; primary ductal carcinoma, held at ATCC, included in the Cancer Genome Project at the Sanger Institute.

   
Notable Features

A hypo-tetraploid cell line, extremely rearranged, with 48 structural chromosome abnormalities, all cells contain dmin involving chromosomes 1, 3, 11, 13 and hsrs involving chromosomes 21, 3, 19.

   
Representative SKY Karyotype
   
   

80(74-82), -X, der(X)t(10;X;12), der(X)t(X;1), 1x1, der(1)t(1;5), der(1)t(1;10?), i(2q), t(2;15), t(2;6;9;X), t(2;20), 2x2, del(3)x2, i(4p), der(4)t(4;22)(q10;q10)x2, isoder(4;18), 5x4, der(6)t(1;6)(?p11-p12, t(6;11), der(7)t(7p;17)x2, der(7)t(7q;X;7;17), der(7)t(7;11;10), 8x1, der(6;8)(q10;q10), del(8)(p10-pter)x2, t(8;1), t(8;20), 9x1, der(4;9)(p10;q10), der(7;9)(p10;q10), 10x1, del(10), der(10)t(5;10)x2, 11x1, der(11)t(3;11), der(?)(18;11;1), der(11?)t(5;11;1;3), 12x3, 13x1, der(13)t(2;13)(?;p11), der(8;14)(p10;q10)x2, der(14)t(10;14), der(14;22)(q10;q10), 15x1, t(15;19), t(?;15;1), t(15;?), 16x2, der(16)t(16;20), 17x2, der(17?)t(1;17), der(17?)t(6;17), 18x1, der(18?)t(18;22), der(18?)t(15;18), der(?)t(18;5/6?), 19x2, der(19)t(19;1;10), 20x3, der(20)t(20;9;20), 21x1, der(21)t(8;21)?, der(21)t(21;3;X)hsr(21;3), der(22)t(19;22)hsr(19), der(22)t(18;22) a

a in less than 50% of the cells

   
 
Additional Information  


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Breast Cancer Cell Lines