Dr P.A.W. Edwards - Publications

Current Research Interests

Publications

Postgraduate Studentships

Positions Available

Recent Publications

Complex rearrangements of 8p may be driven by the presence of multiple tumour suppressor genes.

BMC Cancer, 2008;8:288 http://www.biomedcentral.com/1471-2407/8/288
Cooke SL, Pole JCM, Chin S-F, Ellis IO, Caldas C, Edwards PAW

Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencing. Nat Genet 2008; 40, 722-9 Campbell, PJ, Stephens, PJ, Pleasance, ED, O'Meara, S, Li, H, Santarius, T, Stebbings, LA, Leroy, C, Edkins, S, Hardy, C, Teague, JW, Menzies, A, Goodhead, I, Turner, DJ, Clee, CM, Quail, MA, Cox, A, Brown, C, Durbin, R, Hurles, ME, Edwards, PA, Bignell, GR, Stratton, MR, Futreal, PA

Array painting reveals a high frequency of balanced translocations in breast cancer cell lines that break in cancer-relevant genes. Oncogene 2008;27(23):3345-59 Howarth, KD, Blood, KA, Ng, BL, Beavis, JC, Chua, Y, Cooke, SL, Raby, S, Ichimura, K, Collins, VP, Carter, NP, Edwards, PA.

Molecular cytogenetic characterization of a unique and complex de novo 8p rearrangement. Am J Med Genet A 2008;146A(9):1166-1172 Cooke, SL, Northup, JK, Champaige, NL, Zinser, W, Edwards, PA, Lockhart, LH, Velagaleti, GV

Homozygous deletions may be markers of nearby heterozygous mutations: The complex deletion at FRA16D in the HCT116 colon cancer cell line removes exons of WWOX. Genes Chromosomes Cancer 2008;47(5):437-47 Alsop, AE, Taylor, K, Zhang, J, Gabra, H, Paige, AJ, Edwards, PA

Sister chromatid junctions in the hyperthermophilic archaeon Sulfolobus solfataricus. EMBO J 2007;26(3):816-24 Robinson, NP, Blood, KA, McCallum, SA, Edwards, PA, Bell, SD.

. Architectures of somatic genomic rearrangement in human cancer amplicons at sequence-level resolution. Genome Res 2007;17(9):1296-303 Bignell, GR, Santarius, T, Pole, JC, Butler, AP, Perry, J, Pleasance, E, Greenman, C, Menzies, A, Taylor, S, Edkins, S, Campbell, P, Quail, M, Plumb, B, Matthews, L, McLay, K, Edwards, PA, Rogers, J, Wooster, R, Futreal, PA, Stratton, MR

Genomic Analysis of the 8p11-12 Amplicon in Familial Breast Cancer. Intl J Cancer, 2007;120(3):714-7 Melchor L, Garcia MJ, Honrado E, Pole JCM, Alvarez S, Edwards PAW, Benítez J.

Co-amplification of 8p12 and 11q13 in breast cancers is not the result of a single genomic event. Genes Chromosomes Cancer 2007;46(5):427-39 Paterson AL, Pole JCM, Blood KA, Garcia MJ, Cooke SL, Teschendorff AE, Wang Y-Z, Chin S-F, Ylstra B, Caldas C, Edwards PAW

A quantum leap in our knowledge of breast cancer mutations Breast Cancer Research [Invited commentary ] 2006; 8 (6) 304- 306 Caldas C, Edwards PAW

High-resolution analysis of chromosome rearrangements on 8p in breast, colon and pancreatic cancer reveals a complex pattern of loss, gain and translocation. Oncogene 2006; 25:5693-5706 JCM Pole C Courtay-Cahen MJ Garcia KA Blood SL Cooke AE Alsop DML Tse C Caldas PAW Edwards

Distribution of Breakpoints on Chromosome 18 in Breast, Colorectal and Pancreatic Carcinoma Cell Lines.
Cancer genetics & Cytogenetics, 2006; 164:97-109 Alsop A, Teschendorff AE, Edwards PAW.

A 1 Mb minimal amplicon at 8p11-12 in breast cancer identifies new candidate oncogenes. Oncogene. 2005;24(33):5235-45 PMID: 15897872 Garcia MJ, Pole JC, Chin SF, Teschendorff A, Naderi A, Ozdag H, Vias M, Kranjac T, Subkhankulova T, Paish C, Ellis I, Brenton JD, Edwards PA, Caldas C.

Chromosome abnormalities in 10 lung cancer cell lines of the NCI-H series analyzed with spectral karyotyping. Cancer Genet Cytogenet 2005;162(1):1-9 . Grigorova, M, Lyman, RC, Caldas, C, Edwards, PA.

Evidence that both genetic instability and selection contribute to the accumulation of chromosome alterations in cancer. Carcinogenesis. 2005; 26:923-930. Gorringe KL, Chin SF, Pharoah P, Staines JM, Oliveira C, Edwards PA, Caldas C.

A recurrent chromosome breakpoint in breast cancer at the NRG1/neuregulin 1/heregulin gene

Cancer Research 2004; 64:6840-4

Huai-En Huang¹, Suet-Feung Chin¹, Christophe Ginestier², Valérie-Jeanne Bardou², José Adélaïde², N. Gopalakrishna Iyer¹, Maria J. Garcia¹, Jessica C. Pole¹, Grace M. Callagy¹, Stephen M. Hewitt³, William J. Gullick⁴, Jocelyne Jacquemier², Carlos Caldas¹, Max Chaffanet², Daniel Birnbaum² & Paul A.W. Edwards¹

Possible causes of chromosome instability: comparison of chromosomal abnormalities in cancer cell lines with mutations in BRCA1, BRCA2, CHK2 and BUB1

Cytogenetic and Genome Research 2004;104:333-340

Grigorova M, Staines JM, Ozdag H, Caldas C, Edwards PAW

A recurrent chromosome translocation breakpoint in breast and pacreatic cancer cell lines targets the heregulin/NRG1 gene

Genes Chromosomes and Cancer 2003; 37: 333-345

Adelaide J., Huang H-E, Murati A., Alsop A.E., Orsetti B., Mozziconacci M-J, Popovici C., Letessier A., Ginestier C., Basset C., Courtay-Cahen C., Jacquemier J., Theillet C., Birnbaum D., Edwards P.A.W., Chaffanet M.

Metastasis: the role of chance in malignancy.

Nature (scientific correspondence) 2002; 419:559-560

Edwards PAW

Drafted revision of chapter 23: Cancer (see Preface and Acknowledgements)

Molecular Biology of the Cell, 4th Edition, Garland, 2002

Edwards, P.A.W. in Alberts, B., Johnson, A., Lewis, J., Raff, M., Roberts, K., and Walter, P.

Spectral karyotyping suggests additional subsets of colorectal cancers characterized by pattern of chromosome rearrangement

Proceedings of the National Academy of Sciences USA 2001; 98(5):2538-2543

Abdel-Rahman W.M., Katsura K., Rens W., Gorman P.A., Sheer D., Bicknell D., Bodmer W.F., Arends M.J.,Wyllie A.H., Edwards P.A.

Non-randon Chromosomal Rearrangements in Pancreatic Cancer Cell Lines Identified by Spectral Karyotyping

International Journal of Cancer 2001; 91(3):350-8

Sirivatanauksorn, V., Sirivatanauksorn, Y., Gorman, P.A., Davidson, J.M., Sheer, D., Moore, P.S., Scarpa, A., Edwards, P.A.W., Lemoine, N.

Molecular Cytogenetic Analysis of Breast Cancer Cell Lines

British Journal of Cancer
2000; 83(10):1309-17

Davidson, J.M., Gorringe, K.L., Chin, S-F., Orsetti, B., Besret, C., Courtay-Cahen, C., Roberts, I., Theillet, C., Caldas, C., Edwards, P.A.W.

Retroviral Expression of Wnt-1 and Wnt-7b Produce Different Effects in Mouse Mammary Epithelium

Journal of Cell Science
2000; 113:2129-38

Naylor, S.M., Smalley, M.J., Robertson, D., Gusterson, B.A., Edwards, P.A.W., Dale, T.C.

Chromosome Translocations in Breast Cancer with Breakpoints at 8p12

Genomics
2000; 66:15-25

Courtay-Cahen, C., Morris, J.S., Edwards, P.A.W.

Evaluation of 24-colour Multi-Fluor-Fluorescence In-Situ Hybridisation (M-FISH) Karyotyping by Comparison with Reverse Chromosome Painting of the Human Breast Cancer Cell Line T47D

Chromosome Research 2000; 8:127-132

Lu, Y-J., Morris, J.S., Edwards, P.A.W., Shipley, J.

The Impact of Developmental Biology on Cancer Research: An Overview

Editorial Overview and Guest editor issue of Cancer Matastasis reviews
2000; 18(2):175-180

Edwards, P.A.W.

Integrin-Linked Kinase Regulates Phosphorylation of Serine 473 of Protein Kinase B by an Indirect Mechanism

Oncogene
1999; 18:8024-8032

Lynch, D.K., Ellis, C.A., Edwards, P.A.W., Hiles, I.D.

The Impaired Mammary Gland Development in Cyl-1^-/- mice during pregnancy and Lactation is Epithelial Cell Autonomous

Developmental Biology
1999; 212:1-11

V. Fantl, P. A. W. Edwards, J H. Steel B.K. Vonderhaar and C. Dickson

Cytogenetic analysis of three breast carcinoma cell lines using reverse chromosome painting

Genes, Chromosomes and Cancer
1997; 20:120-139

Morris, J.S., Carter, N.P., Ferguson-Smith, M.A. and Edwards, P.A.W

Genetic manipulation of mammary epithelium by transplantation

Journal of Mammary Gland Biology and Neoplasia
1996; 1:75-90

Edwards PAW, Abram CL and Bradbury JM

Wnt-4 expression induces a pregnancy-like growth pattern in reconstituted mammary glands in virgin mice

Developmental Biology
1995; 170:553-563

Bradbury JM, Edwards PAW, Niemeyer CC and Dale TC

Essentials of Pathology

Blackwells, Oxford, 1995

Mitchinson, M.J., Arno, J., Edwards, P.A.W., Le Page, R.F.L., Minson, A.C.


Current Research Interests	Publications	Postgraduate Studentships

Complex rearrangements of 8p may be driven by the presence of multiple tumour suppressor genes.	BMC Cancer, 2008;8:288 http://www.biomedcentral.com/1471-2407/8/288	Cooke SL, Pole JCM, Chin S-F, Ellis IO, Caldas C, Edwards PAW
Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencing.	Nat Genet 2008; 40, 722-9	Campbell, PJ, Stephens, PJ, Pleasance, ED, O'Meara, S, Li, H, Santarius, T, Stebbings, LA, Leroy, C, Edkins, S, Hardy, C, Teague, JW, Menzies, A, Goodhead, I, Turner, DJ, Clee, CM, Quail, MA, Cox, A, Brown, C, Durbin, R, Hurles, ME, Edwards, PA, Bignell, GR, Stratton, MR, Futreal, PA
Array painting reveals a high frequency of balanced translocations in breast cancer cell lines that break in cancer-relevant genes.	Oncogene 2008;27(23):3345-59	Howarth, KD, Blood, KA, Ng, BL, Beavis, JC, Chua, Y, Cooke, SL, Raby, S, Ichimura, K, Collins, VP, Carter, NP, Edwards, PA.
Molecular cytogenetic characterization of a unique and complex de novo 8p rearrangement.	Am J Med Genet A 2008;146A(9):1166-1172	Cooke, SL, Northup, JK, Champaige, NL, Zinser, W, Edwards, PA, Lockhart, LH, Velagaleti, GV
Homozygous deletions may be markers of nearby heterozygous mutations: The complex deletion at FRA16D in the HCT116 colon cancer cell line removes exons of WWOX.	Genes Chromosomes Cancer 2008;47(5):437-47	Alsop, AE, Taylor, K, Zhang, J, Gabra, H, Paige, AJ, Edwards, PA
Sister chromatid junctions in the hyperthermophilic archaeon Sulfolobus solfataricus.	EMBO J 2007;26(3):816-24	Robinson, NP, Blood, KA, McCallum, SA, Edwards, PA, Bell, SD.
. Architectures of somatic genomic rearrangement in human cancer amplicons at sequence-level resolution.	Genome Res 2007;17(9):1296-303	Bignell, GR, Santarius, T, Pole, JC, Butler, AP, Perry, J, Pleasance, E, Greenman, C, Menzies, A, Taylor, S, Edkins, S, Campbell, P, Quail, M, Plumb, B, Matthews, L, McLay, K, Edwards, PA, Rogers, J, Wooster, R, Futreal, PA, Stratton, MR
Genomic Analysis of the 8p11-12 Amplicon in Familial Breast Cancer.	Intl J Cancer, 2007;120(3):714-7	Melchor L, Garcia MJ, Honrado E, Pole JCM, Alvarez S, Edwards PAW, Benítez J.
Co-amplification of 8p12 and 11q13 in breast cancers is not the result of a single genomic event.	Genes Chromosomes Cancer 2007;46(5):427-39	Paterson AL, Pole JCM, Blood KA, Garcia MJ, Cooke SL, Teschendorff AE, Wang Y-Z, Chin S-F, Ylstra B, Caldas C, Edwards PAW
A quantum leap in our knowledge of breast cancer mutations	Breast Cancer Research [Invited commentary ] 2006; 8 (6) 304- 306	Caldas C, Edwards PAW
High-resolution analysis of chromosome rearrangements on 8p in breast, colon and pancreatic cancer reveals a complex pattern of loss, gain and translocation.	Oncogene 2006; 25:5693-5706	JCM Pole C Courtay-Cahen MJ Garcia KA Blood SL Cooke AE Alsop DML Tse C Caldas PAW Edwards
Distribution of Breakpoints on Chromosome 18 in Breast, Colorectal and Pancreatic Carcinoma Cell Lines.	Cancer genetics & Cytogenetics, 2006; 164:97-109	Alsop A, Teschendorff AE, Edwards PAW.
A 1 Mb minimal amplicon at 8p11-12 in breast cancer identifies new candidate oncogenes.	Oncogene. 2005;24(33):5235-45 PMID: 15897872	Garcia MJ, Pole JC, Chin SF, Teschendorff A, Naderi A, Ozdag H, Vias M, Kranjac T, Subkhankulova T, Paish C, Ellis I, Brenton JD, Edwards PA, Caldas C.
Chromosome abnormalities in 10 lung cancer cell lines of the NCI-H series analyzed with spectral karyotyping.	Cancer Genet Cytogenet 2005;162(1):1-9 .	Grigorova, M, Lyman, RC, Caldas, C, Edwards, PA.
Evidence that both genetic instability and selection contribute to the accumulation of chromosome alterations in cancer.	Carcinogenesis. 2005; 26:923-930.	Gorringe KL, Chin SF, Pharoah P, Staines JM, Oliveira C, Edwards PA, Caldas C.
A recurrent chromosome breakpoint in breast cancer at the NRG1/neuregulin 1/heregulin gene	Cancer Research 2004; 64:6840-4	Huai-En Huang¹, Suet-Feung Chin¹, Christophe Ginestier², Valérie-Jeanne Bardou², José Adélaïde², N. Gopalakrishna Iyer¹, Maria J. Garcia¹, Jessica C. Pole¹, Grace M. Callagy¹, Stephen M. Hewitt³, William J. Gullick⁴, Jocelyne Jacquemier², Carlos Caldas¹, Max Chaffanet², Daniel Birnbaum² & Paul A.W. Edwards¹
Possible causes of chromosome instability: comparison of chromosomal abnormalities in cancer cell lines with mutations in BRCA1, BRCA2, CHK2 and BUB1	Cytogenetic and Genome Research 2004;104:333-340	Grigorova M, Staines JM, Ozdag H, Caldas C, Edwards PAW
A recurrent chromosome translocation breakpoint in breast and pacreatic cancer cell lines targets the heregulin/NRG1 gene	Genes Chromosomes and Cancer 2003; 37: 333-345	Adelaide J., Huang H-E, Murati A., Alsop A.E., Orsetti B., Mozziconacci M-J, Popovici C., Letessier A., Ginestier C., Basset C., Courtay-Cahen C., Jacquemier J., Theillet C., Birnbaum D., Edwards P.A.W., Chaffanet M.
Metastasis: the role of chance in malignancy.	Nature (scientific correspondence) 2002; 419:559-560	Edwards PAW
Drafted revision of chapter 23: Cancer (see Preface and Acknowledgements)	Molecular Biology of the Cell, 4th Edition, Garland, 2002	Edwards, P.A.W. in Alberts, B., Johnson, A., Lewis, J., Raff, M., Roberts, K., and Walter, P.
Spectral karyotyping suggests additional subsets of colorectal cancers characterized by pattern of chromosome rearrangement	Proceedings of the National Academy of Sciences USA 2001; 98(5):2538-2543	Abdel-Rahman W.M., Katsura K., Rens W., Gorman P.A., Sheer D., Bicknell D., Bodmer W.F., Arends M.J.,Wyllie A.H., Edwards P.A.
Non-randon Chromosomal Rearrangements in Pancreatic Cancer Cell Lines Identified by Spectral Karyotyping	International Journal of Cancer 2001; 91(3):350-8	Sirivatanauksorn, V., Sirivatanauksorn, Y., Gorman, P.A., Davidson, J.M., Sheer, D., Moore, P.S., Scarpa, A., Edwards, P.A.W., Lemoine, N.
Molecular Cytogenetic Analysis of Breast Cancer Cell Lines	British Journal of Cancer 2000; 83(10):1309-17	Davidson, J.M., Gorringe, K.L., Chin, S-F., Orsetti, B., Besret, C., Courtay-Cahen, C., Roberts, I., Theillet, C., Caldas, C., Edwards, P.A.W.
Retroviral Expression of Wnt-1 and Wnt-7b Produce Different Effects in Mouse Mammary Epithelium	Journal of Cell Science 2000; 113:2129-38	Naylor, S.M., Smalley, M.J., Robertson, D., Gusterson, B.A., Edwards, P.A.W., Dale, T.C.
Chromosome Translocations in Breast Cancer with Breakpoints at 8p12	Genomics 2000; 66:15-25	Courtay-Cahen, C., Morris, J.S., Edwards, P.A.W.
Evaluation of 24-colour Multi-Fluor-Fluorescence In-Situ Hybridisation (M-FISH) Karyotyping by Comparison with Reverse Chromosome Painting of the Human Breast Cancer Cell Line T47D	Chromosome Research 2000; 8:127-132	Lu, Y-J., Morris, J.S., Edwards, P.A.W., Shipley, J.
The Impact of Developmental Biology on Cancer Research: An Overview	Editorial Overview and Guest editor issue of Cancer Matastasis reviews 2000; 18(2):175-180	Edwards, P.A.W.
Integrin-Linked Kinase Regulates Phosphorylation of Serine 473 of Protein Kinase B by an Indirect Mechanism	Oncogene 1999; 18:8024-8032	Lynch, D.K., Ellis, C.A., Edwards, P.A.W., Hiles, I.D.
The Impaired Mammary Gland Development in Cyl-1^-/- mice during pregnancy and Lactation is Epithelial Cell Autonomous	Developmental Biology 1999; 212:1-11	V. Fantl, P. A. W. Edwards, J H. Steel B.K. Vonderhaar and C. Dickson
Cytogenetic analysis of three breast carcinoma cell lines using reverse chromosome painting	Genes, Chromosomes and Cancer 1997; 20:120-139	Morris, J.S., Carter, N.P., Ferguson-Smith, M.A. and Edwards, P.A.W
Genetic manipulation of mammary epithelium by transplantation	Journal of Mammary Gland Biology and Neoplasia 1996; 1:75-90	Edwards PAW, Abram CL and Bradbury JM
Wnt-4 expression induces a pregnancy-like growth pattern in reconstituted mammary glands in virgin mice	Developmental Biology 1995; 170:553-563	Bradbury JM, Edwards PAW, Niemeyer CC and Dale TC
Essentials of Pathology	Blackwells, Oxford, 1995	Mitchinson, M.J., Arno, J., Edwards, P.A.W., Le Page, R.F.L., Minson, A.C.