Mike Clark's Reprints and Preprints

A full listing of Mike Clark's publications is available as a separate webpage. Listed below is a selection of locally available preprints and reprints.

1. Armour, K.L., Smith, C.S. & Clark, M.R. J. Immunol. Meth. (2010) 354: 20-33 Expression of human FcgRIIIa as a GPI-linked molecule on CHO cells to enable measurement of human IgG binding [Reprint]
2. Goodman, R.S., Kirton, C.M., Oostingh, G.J., Schön, M.P., Clark, M.R., Bradley, J.A., & Taylor, C.J. Transplantation (2008) 85: 471-477 PECAM-1 polymorphism affects monocyte adhesion to endothelial cells [Reprint]
3. Ghevaert, C., Wilcox, D.A., Fang, J., Armour, K.L., Clark, M.R., Ouwehand, W.H., & Williamson, L.M. Journal of Clinical Investigation (2008) 118: 2929-2938 Developing recombinant HPA-1a-specific antibodies with abrogated Fc-gamma receptor binding for the treatment of fetomaternal alloimmune thrombocytopenia [Reprint]
4. Clark, M., in Waldmann, H. (ed.), Monoclonal Antibodies as Therapeutic Agents: Fundamentals, Therapeutic Applications and Latest Advances, The Biomedical & Life Sciences Collection, Henry Stewart Talks Ltd, London (2007) "Antibody Engineering of Fc Effector Functions" (online at http://www.hstalks.com/?t=BL0471360-Clark)
5. Clark, M., in Waldmann, H. (ed.), Monoclonal Antibodies as Therapeutic Agents: Fundamentals, Therapeutic Applications and Latest Advances, The Biomedical & Life Sciences Collection, Henry Stewart Talks Ltd, London (2007) "Fc Receptors and Antibody Effector Functions" (online at http://www.hstalks.com/?t=BL0471316-Clark)
6. Clark, M., Colombel, J-F., Feagan, B.C., Fedorak, R.N., Hanauer, S.B., Kamm, M.A., Mayer, L., Reguiro, C., Rutgeerts, P., Sandborn, W.J., Sands, B.E., Schreiber, S., Targan, S. Travis, S. & Vermeire, S. Gastroenterology (2007) 133: 312-339 American Gastroenterological Association consensus development conference on the use of biologics in the treatment of Inflammatory Bowel Disease, June 21-23, 2006 [Reprint]
7. Wiggington, S.J., Furtado, P.B., Armour, K.L., Clark, M.R., Robins, A., Emara, M., Ghaemmaghami, A.M., Sewell, H.F., & Shakib, F. Clinical and Experimental Allergy (2007) An immunoglobulin E-reactive chimeric human immunoglobulin G1 anti-idiotype inhibits basophil degranulation through cross-linking of FceRI with FcgRIIb [Reprint]
   
8. Armour, K.L., Parry-Jones, D.R., Beharry, N., Ballinger, J.R., Mushens, R., Williams, R.K., Beatty, C., Stanworth, S., Lloyd Evans, P., Scott, M., Clark, M.R., Peters M, & Williamson, L.M. Blood (2006) 107: 2619-2626 Intravascular survival of red cells coated with a mutated human anti-D antibody engineered to lack destructive activity [Reprint]
   
9. Shankar, V., Kools, J.J., Armour, K.L. & Clark, M.R. Hybridoma (2005) 24: 50-54 A chimeric antibody to varicella-zoster virus glycoprotein E
10. Kirton, C. M., Laukkanen, M-L., Nieminen, A., Merinen, M., Stollen, C., Armour, K., Smith, D.J., Salmi, M., Jalkanen, S., & Clark, M.R. Eur. J. Immuno. (2005) 35: 3119-3130 Function-blocking antibodies to human vascular adhesion protein-1: A potential anti-inflamatory therapy [Reprint]
    
11. Joutsi-Korhonen, L., Preston, S., Smethurst, P.A., Ijsseldijk, M., Schaffner-Reckinger, E., Armour, K.L., Watkins, N.A., Clark, M.R., de Groot, P.G., Farndale, R.W., Ouwehand, W.H., & Williamson, L.M. Thrmobosis and Haemostasis (2004) 91: 743-754 The effect of recombinant IgG antibodies against the leucine-33 form of the platelet beta 3 integrin (HPA-1a) on platelet function
12. Armour, K.L., van de Winkel, J.G.J., Williamson, L.M., & Clark, M.R. Molecular Immunology (2003) 40: 585-593 Differential binding to human Fc-gamma-RIIa and Fc-gamma-RIIb receptors by human IgG wildtype and mutant antibodies [Reprint]
    
13. Clark, M. (2002), The Biochemist 24:4, 48-49 Obituary: César Milstein (1927-2002) [Reprint]
    
14. Armour, K.L., Atherton, A., Williamson, L.M. & Clark, M.R. (2002), Biochem Soc Trans 30, 495-500 The contrasting IgG-binding interactions of human and herpes simplex virus Fc receptors
    [Reprint]
    
15. Furtado, P.B., McElveen, J.E., Gough, L., Armour, K.L., Clark, M.R., Sewell, H.F., & Shakib, F. (2002), J. Clin Pathol: Mol Pathol 55, 315-324 The production and characterisation of a chimaeric human IgE antibody, recognising the major mite allergen Der p 1, and its chimaeric human IgG1 anti-idiotype
    [Reprint]
    
16. Jaakkola, K., Nikula, T., Holopainen, R., Vahasilta, T., Matikainen, M-T., Laukkanen, M-L., Huupponen, R., Halkola, L., Nieminen, L., Hiltunen, J., Parviainen, S., Clark, M.R., Knuuti, J., Savunen, T., Kaapa, P., Voipio-Pulkki, L.M., & Jalkanen, S. (2000), American Journal of Pathology 157, 463-471 In Vivo Detection of Vascular Adhesion Protein-1 in Experimental Inflammation
    [Reprint]
    
17. Garner, S.F., Smethurst, P.A., Merieux, Y., Aeby, C., Smith G., Armour, K.L., Scott, M.L., Williamson, L.M., Metcalf, P. Goodall, A.H., Clark, M.R., Rigal, D., Schawaller, M. & Ouwehand, W.H. (2000), British Journal of Haematology 108, 440-447 A rapid one-stage whole-blood HPA-1a phenotyping assay using a recombinant monoclonal IgG1 anti-HPA-1a
    [Reprint]
    
18. Atherton, A., Armour, K.L., Bell, S., Minson, A.C., and Clark, M.R. (2000), Eur J. Immunol. 30: 2540-547 The Herpes Simplex Virus Type 1 Fc Receptor Discriminates between IgG1 Allotypes.
    [Reprint]
    
19. Clark, M (2000), Immunology Today 21, 397-402 Antibody humanisation: a case of the 'Emperor's new clothes'?
    [Preprint] [Reprint]
    
20. Clark, M (2000), Immunology Today 21, 412 Book Review: Recombinant Antibodies by Frank Breitling and Stefan Dubel
    [Reprint]
    
21. McElveen, J.E., Furtado, P.B., Smith, S.J., Clark, M.R., Spendlove, I., Sewell, H.F. & Shakib, F. (2000), J Clin Pathol: Mol Pathol 53, 77-82 Characterisation of a mouse monoclonal anti-idiotype reactive with a V-region sequence commonly used by human immunoglobulins.
    [Reprint]
    
22. Furmonaviciene, R., Tighe, P.J., Clark, M.R., Sewell, H.F. & Shakib, F. (1999), Clin Exp Allergy 29: 1563-1571 The use of phage-peptide libraries to define the epitope specificity of a mouse monoclonal anti-Der p 1 antibody representative of a major component of the human IgE anti-Der p 1 response.
    [Reprint]
    
23. Armour, K.L., Clark, M.R., Hadley, A.G. & Williamson L.M. (1999), Eur J Immunol 29: 2613-2624 Recombinant human IgG molecules lacking Fc-gamma Receptor I binding and monocyte triggering activities
    [Reprint]
    
24. Watkins, N.A., Armour, K.L., Smethurst, P.A., Metcalfe, P., Scott, M.L., Hughes, D.L., Smith, G.A., Williamson, L.M., Clark, M.R. & Ouwehand, W.H. (1999), Transfusion 39: 781-789 Rapid human platelet antigen-1a phenotyping using either diabody based haemagglutination or recombinant IgG1 based assays
    [Reprint]
    
25. McElveen,J., Clark,M.R., Smith,S.J., Sewell,H.F. & Shakib,F. (1998), Clin Exp Allergy 28, 1427-1434 Primary sequence and molecular model of the variable region of a mouse monoclonal anti-Der p I antibody showing a similar epitope specificity as human IgE.
    [Reprint]
    
26. Redpath, S., Michaelsen, T.E., Sandlie, I. & Clark, M.R. (1998), Human Immunology 59, 720-727 The influence of the hinge region length in binding of human IgG to human Fc gamma receptors.
    [Reprint]
    
27. Redpath,S., Michaelsen,T., Sandlie,I., & Clark,M.R. (1998), Immunology 93, 595-600 Activation of complement by human IgG1 and human IgG3 antibodies against the human leucocyte antigen CD52
    [Reprint]
    
28. Clark, M (1997), Chemical Immunology 65, 88-110 Antibody Engineering IgG Effector Mechanisms
    [Preprint]
    
29. Greenwood,J., & Clark,M. (1993), pp. 85-100 Protein engineering of antibody molecules for prophylactic and therapeutic applications in man. Effector functions of matched sets of recombinant human IgG subclass antibodies.
    [Complete HTML], [Text Preprint], [Figures Preprint]
30. Routledge,E.G., Gorman,S.D., & Clark,M. (1993), pp. 13-44 Protein engineering of antibody molecules for prophylactic and therapeutic applications in man. Reshaping antibodies for therapy.
    [Complete HTML], [Text Preprint], [Figures Preprint], [Tables Preprint]
31. Gorman,S.D, & Clark,M.R. (1990), Seminars in Immunology 2, 457-466 Humanisation of monoclonal antibodies for therapy
    [Preprint]
32. Brüggemann, M., Williams, G.T., Bindon, C.I., Clark, M.R., Jefferis, R., Waldmann, H. & Neuberger, M.S. Journal of Experimental Medicine (1987) 166: 1351-1361 Comparison of the effector functions of human immunoglobulins using a matched set of chimeric antibodies. [Reprint]
33. Hale, G., Clark, M. & Waldmann, H. Journal of Immunology (1985) 134: 3056-3061 Therapeutic potential of rat monoclonal antibodies: Isotype specificity of antibody-dependent cell-mediated cytotoxicity with human lymphocytes [Reprint]