Undergraduate immunology course lecture notes from Mike Clark

• Antibody and T-cell Receptors: structure and Function (Updated November 2011)
  1. Lecture 1 materials
     1. Powerpoint slides (1st November 2011)
     2. Supplementary handout on Antibodies and T-cell receptors
     3. Immunoglobulin sequences
     4. Supplementary handout on Antibody structure and Fc Receptors
  2. Lecture 2 materials (Updated November 2011)
     1. Immunoglobulin genes (19th October 2010)
     2. T-cell receptors (21st October 2010)
     3. Supplementary powerpoint slides (3rd November 2011)
     4. Supplemetary powerpoint slides (Courtesy of Dr Michael Neuberger)
• PDF format lecture notes on antibody affinity
  1. Supplementary lecture materials
     1. Antibody affinity
• Extra external resources
  1. PLoS Biology: Primer on VDJ recombination
  2. An interactive 3D molecular presentation of antibody structure from Eric Martz
  3. An interactive 3D molecular presentation of the mouse IgG2a crystal structure (PDB structure 1IGT)
  4. An interactive 3D molecular presentation of TCR complexed with MHC (PDB structure 1AO7)
• Lectures on therapeutic applications of antibodies
  1. Powerpoint presentation 5th March 2009
  2. Powerpoint presentation given to Cambridge Masters in BioSciences and also to Nottingham MSc Courses, part 1
  3. Powerpoint presentation given to Cambridge Masters in BioSciences and also to Nottingham MSc Courses, part 2
• PDF format preprints and reprints of some of Mike's articles
  1. Clark, M (1997), Chemical Immunology 65, 88-110 IgG Effector Mechanisms
  2. Armour et al (2002), Biochem Soc Trans 30, 495-500 The contrasting IgG-binding interactions of human and herpes simplex virus Fc receptors
  3. Clark, M (2000), Immunology Today 21, 397-402 Antibody humanisation: a case of the 'Emperor's new clothes'?
  4. Other recent publications from the Clark group available locally

The text and illustrations provided on this web page are provided for my undergraduate teaching in Cambridge and unless otherwise stated are © copyright M.R. Clark, PhD., Reader in Therapeutic and Molecular Immunology, Department of Pathology, Cambridge University, Cambridge UK CB2 1QP. The information provided is to the best of my knowledge correct but if you are aware of any errors please do contact me.

This page is from Mike Clark
"An antibody engineer who also enjoys the mountains."
mrc7@cam.ac.uk
Mike's home-page

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© Mike Clark, PhD., Cambridge University, UK
Last updated on 3rd November 2011