The Therapeutic Antibody Human Homology Project is my attempt to group therapeutic monoclonal antibodies which have been used in human therapeutic trials according to their homologies with human germline immunoglobulin genes. My hope is that this will make it easier to identify whether there is any correlation between the efficacy of these antibodies (particularly regarding immune responses to the antibody) and the sequences of the variable regions.
Therapeutic antibodies these days are frequently classified as 'chimaeric', 'humanised', 'human' or 'fully human' antibodies. However my initial analysis of antibodies grouped this way identified that the name does not give a clear indication of how homologous to human sequences a therapeutic antibody is [see a summary of this data here]. This is because of conservation of immunoglobulin sequences between species.
The project is my own academic initiative prompted by my research and teaching interests in the field of therapeutic immunology. I intend to develop the project and publish the results on these web pages in a way which makes the data transparent to the reader and thus of use to the wider academic community. This project will be updated and continued as and when I can find time from my other teaching and research duties.
The methodology I plan to use is very simple and has already been outlined in a review by Ed Routledge, Scott Gorman and myself published in 1993 ["Reshaping antibodies for therapy" Edward G. Routledge, Scott D. Gorman and Mike Clark, in Protein Engineering of Antibody Molecules for Prophylactic and Therapeutic Applications in Man pp.13-44 (1993) edited by Mike Clark publisher, Academic Titles, Nottingham, England ISBN 1 874695 00 8] and available on this website as an online readable source.
You can find the results of the TAHHP analysis from the following links.
This project requires that I identify the correct sequences which go along with each therapeutic antibody. Unfortunately most antibodies go through multiple name changes during their commercial development. This makes it rather time consuming to track the antibodies currently in trials back to the description of their original sequences. However if you are able to point me to details of a therapeutic antibody and it's sequence I will endeavour to include it in the list. Please remember that I only wish to include sequences and data which is in the public domain and readily verifiable as such. Also of value would be published details of antiglobulin responses to these antibodies and I will eventually try to cross reference this data.A list of some therapeutic antibodies I would like some further information on can be found on the web page given below..
You can email me as firstname.lastname@example.org
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