Professor Colin Hughes
Key publications
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Koronakis V, Sharff A, Koronakis E, Luisi B, Hughes C (2000). Crystal structure of TolC central to multidrug efflux and protein export.
Nature 405: 914
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Andersen C, Koronakis E, Bokma E, Eswaran J, Humphreys D, Hughes C, Koronakis V (2002). Transition to the open state of the TolC periplasmic tunnel entrance.
Proceedings of the National Academy of Sciences (USA) 99:11103-11108. -
Higgins M, Boekma E, Koronakis E, Hughes C, Koronakis V (2004). Structure of the periplasmic component of a bacterial antibiotic efflux pump.
Proceedings of the National Academy of Sciences (USA) 101:9994-9999. -
Thomas J, Stafford GP, Hughes C (2004). Docking of export chaperone-substrate complexes at the membrane ATPase during flagellar type III protein export.
Proceedings of the National Academy of Sciences (USA) 101:3945-3950. - Higgins M, Eswaran J, Edwards P, Schertler G F X, Hughes C and Koronakis V (2004). Structure of the ligand-blocked periplasmic entrance of the bacterial multidrug efflux protein TolC
Journal of Molecular Biology 342: 697 - Evans L, Stafford G P, Ahmed S, Fraser G M, and Hughes C (2006). An escort mechanism for cycling export chaperones.
Proceedings of the National Academy of Sciences (USA) 103: 17474 - Stafford G P, Evans L, Krumscheid R, Dhillon P, Fraser G and Hughes C (2007). Sorting of early and late flagellar subunits after docking at the membrane ATPase of the type III export pathway.
Journal of Molecular Biology 374: 877 - Lobedanz S, Bokma E, Symmons M, Koronakis E, Hughes C, and Koronakis V (2007). A coiled-coil interface underlying TolC recruitment and pump assembly.
Proceedings of the National Academy of Sciences (USA) 104: 4612 - Symmons MF, Bokma E, Koronakis E, Hughes C, Koronakis V (2009). The assembled structure of a tripartite multidrug efflux pump.
Proceedings of the National Academy of Sciences 1106: 7173 - Pei XY, Hinchliffe P, Symmons MF, Koronakis E, Benz R, Hughes C, Koronakis V. (2011)
Structures of sequential open states in a symmetrical opening transition of the TolC exit duct.
Proceedings of the National Academy of Sciences (USA) 108:2112-2117.