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Remodelling of the mammalian host cell cytoskeleton by the intracellular bacterial pathogen Salmonella

Remodelling of the mammalian host cell cytoskeleton by the intracellular bacterial pathogen Salmonella

Based at Department of Pathology, Tennis Court Road
Supervised by Professor Vassilis Koronakis

Background

The bacterial pathogen Salmonella injects virulence effector proteins into intestinal epithelial cells that hijack the WAVE regulatory complex (WRC). Bacterial subversion of the WRC triggers remodelling of the actin cytoskeleton that mediates Salmonella macropinocytosis into the host cell where the pathogen establishes infection. Our laboratory has identified a novel cellular activator of the WRC known as Arf GTPase that cooperates with Rac1 GTPase to control WRC. Besides its role in infection, the WRC is pivotal to cell movement, architecture and development, and underlies many pathologies, e.g. cancer. Understanding how WRC functions will unveil new disease mechanisms and fundamental cell biology.

Recent Publications:

Greene NP, et al Proc Natl Acad Sci U S A. (2015 )Jun 9;112(23):

Davidson AC et al MBio. (2015) Feb 10;6(1).

Hinchliffe P et al FEBS Lett. (2014) Aug 25;588(17):3147-53.

Humphreys D,et al Proc Natl Acad Sci U S A. (2013) 110(42):16880-5      

Greene NP et al FEBS Lett. (2013) Sep 17;587(18):2984-8.

More information on the supervisor’s research can be found on their research group website
http://www.path.cam.ac.uk/directory/vassilis-koronakis