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Innate immune sensing of high- and low- risk papillomaviruses

Innate immune sensing of high- and low- risk papillomaviruses

Based at Department of Pathology, Tennis Court Road
Supervised by Dr Brian Ferguson and Dr John Doorbar

Background

The high-risk human papillomaviruses (HPVs) are responsible for the majority of cervical cancers and for a growing proportion of head and neck cancers. By contrast, low-risk papillomaviruses cause benign self-limiting papillomas, despite sharing a broadly similar genome organisation. The molecular, cellular and immunological bases for these profound differences in life-cycle organisation and disease-associations offer important insights into host and virus biology, and hopefully will lead eventually to targeted therapies. In this project we aim to understand the role of the innate immune response during the normal productive low and high risk HPV life-cycle, and how these viruses combat these defences.

Recent Publications:

Doorbar,J. (2016) Model Systems of HPV-Associated Disease. J.Pathol Oct 12. [Epub ahead of print] PMID: 26456009

BJ Ferguson, S Newland, SE Gibbs, P Tourlomousis, P Fernandes dos Santos, MN Patel, SW Hall, H Walczak, G Schramm, H Haas, DW Dunne, A Cooke, and P Zaccone (2016) The Schistosoma mansoni T2 ribonuclease omega-1 modulates inflammasome-dependent IL-1beta secretion in macrophages. International Journal for Parasitology (In Press)

Egawa N, Egawa K, Griffin H, Doorbar J. (2015) Human Papillomaviruses; Epithelial Tropisms, and the Development of Neoplasia. Viruses16;7(7):3863-90 PMID: 26193301                                            

Griffin H, Soneji Y, Van Baars R, Arora R, Jenkins D, van de Sandt M, Wu Z, Quint W, Jach R, Okon K, Huras H, Singer A, Doorbar J. (2015) Stratification of HPV-induced cervical pathology using the virally encoded molecular marker E4 in combination with p16 or MCM. Mod Pathol. 28(7):p977-93. PMID: 25953390

H Ren, BJ Ferguson, C Maluquer de Motes, RP Sumner, L Harman, GL Smith (2015) Enhancement of CD8+ T‐cell memory by removal of a vaccinia virus NF‐κB inhibitor. Immunology 145 (1), 34-49

More information on the supervisor’s research can be found on their research group website

http://www.path.cam.ac.uk/directory/brian-ferguson

http://www.path.cam.ac.uk/directory/john-doorbar