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Anti-viral functions of the DNA repair machinery

Supervisor: Dr Brian Ferguson
Division: Immunology
Based at Department of Pathology, Tennis Court Road, Cambridge

Project title: Anti-viral functions of the DNA repair machinery

Sensing of viral genomes inside cells is essential for initiating the host defence against these pathogens. The initial production of type1 interferons and cytokines in the first infected cells depends on intracellular sensing of viral DNA by pattern recognition receptors in the cytoplasm. Our laboratory is focussed on understanding how the DNA repair machinery contributes to this process to help fight of DNA viruses. This project aims to understand how proteins of the non-homologous end-joining pathway regulate innate immunity and restrict herpesvirus infections. 

Recent publications:

  1. LUBAC deficiency perturbs TLR3 signaling to cause immunodeficiency and autoinflammation
    J Zinngrebe, E Rieser,L Taraborrelli,N Peltzer, T Hartwig, H Ren, I Kovács, C Endres, P Draber, M Darding, S von Karstedt, J Lemke, B Dome, M Bergmann , BJ Ferguson*, H Walczak*
    J Experimental Medicine (In Press)
  2. Increased attenuation but decreased immunogenicity by deletion of multiple vaccinia virus immunomodulators
    RP Sumner, H Ren, BJ Ferguson, GL Smith
    Vaccine (2016), Volume 34, Pages 4827–4834
  3. The Schistosoma mansoni T2 ribonuclease omega-1 modulates inflammasome-dependent IL-1beta secretion in macrophages
    BJ Ferguson, S Newland, SE Gibbs, P Tourlomousis, P Fernandes dos Santos, MN Patel, SW Hall, H Walczak, G Schramm, H Haas, DW Dunne, A Cooke, and P Zaccone
    International Journal for Parasitology (2015), Volume 45, Pages 809–813
  4. Functions of DNA damage machinery in the innate immune response to DNA virus infection
    BJ Trigg and BJ Ferguson
    Current Opinion in Virology (2015), Volume 15, Pages 56–62
  5. Enhancement of CD8+ T‐cell memory by removal of a vaccinia virus NF‐κB inhibitor H Ren, BJ Ferguson, C Maluquer de Motes, RP Sumner, L Harman, GL Smith
    Immunology (2015), 145 (1), 34-49