Non-opsonic phagocytosis during Plasmodium falciparum malaria infection
Based at Department of Pathology, Tennis Court Road
Supervised by Dr Katerina Artavanis-Tsakonas
During malaria infection, phagocytosis plays a critical role in parasite clearance and recovery. Yet, little is known about which receptors on host antigen-presenting cells (APCs) are responsible for recognizing parasites and initiating uptake. We aim to characterize how APCs interact with and mediate uptake of parasitized red blood cells (pRBC) during malaria infection. Characterizing elements of antigen recognition and processing will help guide rational vaccine design for a disease currently lacking in prophylactic treatment options.
Morrow ME, Kim M, Ronau JA, Sheedlo MJ, White RR, Chaney J, Paul LN, Lill M, Artavanis-Tsakonas K, Das C. Structural analysis of ubiquitin recognition by the proteasome-associated deubiquitinase UCH37 from Trichinella spiralis. Biochemistry. 2013, 52 (20): 3564-3578
White RR and Artavanis-Tsakonas K. The effects of helminth-derived excretory-secretory products on host dendritic cells. Virulence. 2012, Nov 15(3): 668-677. (Invited Review)
White RR, Miyata S, Papa E, Spooner E, Selkirk ME, Gounaris K, Artavanis-Tsakonas K. Characterisation of the Trichinella spiralis deubiquitinating Enzyme,TsUCH37, an Evolutionarily Conserved Proteasome Interaction Partner. PLoS NTD. 2011, Oct 4(10):e1340.
Artavanis-Tsakonas K, Kasperkovitz PV, Papa E, Cardenas ML, Khan NS,Van der Veen AG,Ploegh HL,Vyas JM. The tetraspanin CD82 is specifically recruited to fungal and bacterial phagosomes prior to acidification. Infec Immun. 2011, Mar;79(3):1098-106.
Artavanis-Tsakonas K, Weihofen WA, Antos JM, Coleman BI, Comeaux CA, Duraisingh MT, Gaudet R, Ploegh HL. Structural studies and characterization of the Plasmodium falciparum ubiquitin and Nedd8 hydrolase UCHL3. J Biol Chem. 2010, Feb 26;285(9):6857-66.